Chorionic gonadotropin stimulates maternal hepatocyte proliferation during pregnancy.
Chorionic gonadotropin stimulates maternal hepatocyte proliferation during pregnancy.
复制标题
DOI：
10.1016/j.bbrc.2021.09.039
复制
发表时间：
2021-11-19
影响因子：
3.1
通讯作者：
Imai T
中科院分区：
文献类型：
--
作者：
Cho J;Tsugawa Y;Imai Y;Imai T
在怀孕期间，肝脏会增大，以适应与怀孕有关的代谢需求。我们之前的研究表明，小鼠妊娠期间母肝细胞增殖增加，雌二醇（E2）是负责母肝细胞增殖的候选激素之一。在这里，我们发现绒毛膜促性腺激素（CG）诱导妊娠期间母体肝细胞增殖。在未怀孕小鼠和细胞培养系统中，给药CG足以刺激肝细胞增殖。我们得出结论，CG刺激妊娠早期母体肝细胞的增殖。相反，雌激素在妊娠后期刺激肝细胞增殖。
The liver increases its size during pregnancy to adapt to metabolic demand associated with pregnancy. Our previous study showed that proliferation of maternal hepatocytes are increased during pregnancy in mice and that estradiol (E2) is one of the candidate hormones responsible for maternal hepatocyte proliferation. Here, we discovered that chorionic gonadotropin (CG) induces maternal hepatocyte proliferation during pregnancy. CG administration was sufficient to stimulate hepatocyte proliferation in non-pregnant mice as well as in cell culture system. We conclude that CG stimulates proliferation in the early pregnancy of maternal hepatocytes. In contrast, estrogen stimulates hepatocyte proliferation in the late pregnancy.
登录
查看更多内容
影响因子：
3.1
作者：
FRANCAVILLA, A;GAVALER, JS;STARZL, TE
通讯作者：
STARZL, TE
影响因子：
4.3
作者：
Yoshida K;Ono F;Chouno T;Perocho BR;Ikegami Y;Shirakigawa N;Ijima H
通讯作者：
Ijima H
影响因子：
3.6
作者：
Liu, Xingjun;Wang, Hai;Gong, Zhiyuan
通讯作者：
Gong, Zhiyuan
影响因子：
2.1
作者：
Uebi, Tatsuya;Umeda, Makoto;Imai, Takeshi
通讯作者：
Imai, Takeshi
影响因子：
2.4
作者：
Umeda, Makoto;Hiramoto, Masaki;Imai, Takeshi
通讯作者：
Imai, Takeshi