Hydralazine-induced tumor hypoxia: a potential target for cancer chemotherapy.
Hydralazine-induced tumor hypoxia: a potential target for cancer chemotherapy.
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肼屈嗪诱导的肿瘤缺氧：癌症化疗的潜在目标。
DOI：
10.1093/jnci/81.8.618
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发表时间：
1989
期刊：
影响因子：
--
通讯作者：
Chaplin,DJ
中科院分区：
文献类型：
--
作者：
Chaplin,DJ
目前可用的癌症化疗剂已被设计成利用已知存在于宿主细胞和恶性细胞之间的增殖和生物化学的细微差异。然而，化疗剂也可用于利用癌症和正常组织之间的生理差异。本研究旨在确定血管扩张剂肼苯哒嗪诱导的肿瘤血流量（以及氧输送）减少是否会增加已知在氧合减少区域毒性更大的药物的细胞毒性。用三种鼠肿瘤模型获得的结果清楚地表明肼苯哒嗪增强这些药剂的肿瘤细胞毒性的程度大于其全身毒性。这项研究表明了一个潜在的战略，提高某些癌症化疗药物的疗效在固体himors。[J Natl Cancer Inst 81：618-622，1989]
Currently available cancer chemotherapeutic agents have been designed to exploit subtle differences In proliferation and biochemistry that are known to exist between host and malignant cells. However, chemotherapeutic agents may also be used to exploit physiological differences between cancer and normal tissue. The present study was conducted to determine whether the reduction In blood flow to the tumor (and thus oxygen delivery) induced by the vasodilator hydralazine would Increase the cytotoxicity of drugs known to be more toxic in regions of reduced oxygenation. Results obtained with three murine tumor models clearly demonstrate that hydralazine potentiates the tumor cytotoxicity of such agents to a greater extent than it does their systemic toxicity. This study indicates a potential strategy for increasing the efficacy of certain cancer chemotherapeutic agents in solid himors. [J Natl Cancer Inst 81:618–622, 1989]
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影响因子：
6.5
作者：
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通讯作者：
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鼠角质形成细胞的亚细胞制剂对花生四烯酸的脂氧合。
DOI：
10.1111/1523-1747.ep12340250
发表时间：
1984
期刊：
The Journal of investigative dermatology
影响因子：
--
作者：
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通讯作者：
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DOI：
10.1111/1523-1747.ep12522659
发表时间：
1983
期刊：
The Journal of investigative dermatology
影响因子：
--
作者：
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通讯作者：
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影响因子：
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作者：
Lawrence M. Solomon;M Barry Kirschenbaum;Lennart Juhlin
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