Emotional state alters encoding of long-term spatial episodic memory.
Emotional state alters encoding of long-term spatial episodic memory.
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DOI：
10.1016/j.nlm.2021.107562
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发表时间：
2022-01
影响因子：
2.7
通讯作者：
Vazdarjanova, Almira
中科院分区：
文献类型：
--
作者：
Dixon-Melvin, Rachael;Shanazz, Khadijah;Nalloor, Rebecca;Bunting, Kristopher M.;Vazdarjanova, Almira
情绪和情景记忆的神经生物学是研究得很好的主题，它们的交叉点：情绪事件的记忆（即情绪记忆）。我们和其他人之前已经证明，刺激的情绪效价是在背侧海马体中编码的，背侧海马体是一个与长期情景记忆的获得、巩固和检索不可或缺的结构。这些发现与刺激的情绪效价对情景记忆的“什么”成分（“在哪里”和“何时”是其他成分）有贡献的观点是一致的。我们假设，处于高度情绪状态本身并不会对情景记忆中的“什么”成分产生影响。我们测试了这一假设的推论-消极的情绪状态不会改变空间情节事件的重新编码。来自实验组的大鼠在其基线情绪状态下探索了一个新的地方（事件1），20分钟后在事件2之前由状态改变事件诱导的负面情绪状态下重新探索了同一个地方（事件2）。我们研究了在这两个事件中诱导Arc和Homer 1a表达的神经元集合，这两个即刻早期基因（IEGs）是突触可塑性和长期记忆巩固所必需的。我们发现，在背侧CA 1和背侧CA 3，事件1和事件2诱导IEG表达在不同的神经元系综。这一发现反映在较低的保真度评分中，该评分评估了在事件2期间重新激活的事件1的IEG表达集合的百分比。在事件2期间处于基线情绪状态的对照组中，保真度分数显著更高。与状态改变事件的非特异性中断相匹配的组在背侧CA 1中具有中间的保真度分数。后两组背侧CA 3区Fidelity评分与对照组相似。结合起来，研究结果拒绝了测试的假设，并表明，一个负面的情绪状态是在海马体编码的一部分，缺乏明确的情绪诱导刺激的情节性事件的长期记忆。这些发现还表明，经常经历强烈负面情绪状态的人会将这些状态纳入持续的非情绪情景记忆中。
The neurobiology of emotion and episodic memory are well-researched subjects, as is their intersection: memory of emotional events (i.e. emotional memory). We and others have previously demonstrated that the emotional valence of stimuli is encoded in the dorsal hippocampus, a structure integral to the acquisition, consolidation and retrieval of long-term episodic memories. Such findings are consistent with the idea that the emotional valence of stimuli contributes to the “what” component of episodic memories (“where” and “when” being the other components). We hypothesize that being in a heightened emotional state by itself does not contribute to the ”what” component of episodic memories. We tested an inference of this hypothesis - that negative emotional state does not alter re-encoding of a spatial episodic event. Rats from the experimental group explored a novel place at their baseline emotional state (Event 1) and 20 minutes later re-explored the same place (Event 2) in a negative emotional state induced by a state-altering event prior to Event 2. We examined neuronal ensembles that induced expression of Arc and Homer1a, two immediate-early genes (IEGs) necessary for synaptic plasticity and consolidation of long-term memories, during both events. We found that in dorsal CA1 and dorsal CA3, Event 1 and Event 2 induced IEG expression in different neuronal ensembles. This finding was reflected in a low Fidelity score, which assesses the percentage of the Event 1 IEG-expressing ensemble re-activated during Event 2. The Fidelity score was significantly higher in a control group which was at a baseline emotional state during Event 2. Groups which were matched for non-specific disruptions from the state-altering event had intermediate Fidelity scores in dorsal CA1. The Fidelity scores of the dorsal CA3 in the latter groups were similar to those of the control group. Combined, the findings reject the tested hypothesis and suggest that a negative emotional state is encoded in the hippocampus as part of the long-term memory of episodic events that lack explicit emotion-inducing stimuli. These findings also suggest that individuals who often experience strong negative emotional states incorporate these states into ongoing non-emotional episodic memories.
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影响因子：
2.7
作者：
Eichenbaum, H
通讯作者：
Eichenbaum, H
影响因子：
56.9
作者：
Leutgeb, S;Letugeb, JK;Moser, MB
通讯作者：
Moser, MB
影响因子：
29.3
作者：
Lindquist, Kristen A.;Wager, Tor D.;Kober, Hedy;Bliss-Moreau, Eliza;Barrett, Lisa Feldman
通讯作者：
Barrett, Lisa Feldman
影响因子：
1.4
作者：
BLANCHARD, RJ;BLANCHARD, DC
通讯作者：
BLANCHARD, DC
DOI：
10.1073/pnas.92.12.5734
发表时间：
1995-06-06
影响因子：
11.1
作者：
LINK, W;KONIETZKO, U;KUHL, D
通讯作者：
KUHL, D