A model of the effect of uncertainty on the C elegans L2/L2d decision.

A model of the effect of uncertainty on the C elegans L2/L2d decision.
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DOI:
10.1371/journal.pone.0100580
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发表时间:
2014
期刊:
影响因子:
3.7
通讯作者:
Avery L
Avery L
中科院分区:
综合性期刊3区
文献类型:
--
作者:
Avery L

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在第一个幼虫阶段结束时,线虫幼虫在两种发育途径之间进行选择,L2致力于生殖发育,L2d可以选择进行生殖发育或进入dauer滞育。我开发了一个定量模型,这种选择使用数学工具开发的金融期权定价。该模型预测,最佳决策必须考虑到不仅是预期的生殖增长潜力,但也在预期的潜力的不确定性。由于L2d比L2具有更大的灵活性,因此在不可预测的环境中更受青睐。我估计,考虑到不确定性的能力可能会增加生殖价值高达5%,并讨论可能的实验测试这种能力。
At the end of the first larval stage, the C elegans larva chooses between two developmental pathways, an L2 committed to reproductive development and an L2d, which has the option of undergoing reproductive development or entering the dauer diapause. I develop a quantitative model of this choice using mathematical tools developed for pricing financial options. The model predicts that the optimal decision must take into account not only the expected potential for reproductive growth, but also the uncertainty in that expected potential. Because the L2d has more flexibility than the L2, it is favored in unpredictable environments. I estimate that the ability to take uncertainty into account may increase reproductive value by as much as 5%, and discuss possible experimental tests for this ability.
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