Estimation of the toxicity of sulfadiazine to Daphnia magna using negligible depletion hollow-fiber liquid-phase microextraction independent of ambient pH.
Estimation of the toxicity of sulfadiazine to Daphnia magna using negligible depletion hollow-fiber liquid-phase microextraction independent of ambient pH.
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DOI：
10.1038/srep39798
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发表时间：
2016-12-22
影响因子：
4.6
通讯作者：
Bai L
中科院分区：
文献类型：
--
作者：
Liu K;Xu S;Zhang M;Kou Y;Zhou X;Luo K;Hu L;Liu X;Liu M;Bai L
可电离的有机化合物对生物体的毒性取决于pH值，因此pH值会影响这些化合物的风险评估。然而，目前还没有一种直接的化学方法来预测可电离有机化合物的毒性。为了确定中空纤维液相微萃取（HF-LPME）是否适用于此目的，采用三相HF-LPME测定了不同pH溶液中磺胺嘧啶的浓度，并评价了其对大型蚤的毒性。结果表明，HF-LPME测定的磺胺嘧啶浓度随pH的升高而降低，这与磺胺嘧啶毒性的降低是一致的。当pH值从6.0增加到8.5时，根据标称浓度计算的48 h内水蚤的浓度（EC 50）从11.93 mg L−1增加到273.5 mg L−1，EC 50值的变异系数（CV）达到104.6%。当根据HF-LPME（pH 12受体相）测量的浓度计算时，EC 50范围为223.4至394.6 mg L−1，CV降至27.60%，表明HF-LPME测量的浓度可用于估计磺胺嘧啶的毒性，而与溶液pH无关。
The toxicity of ionizable organic compounds to organisms depends on the pH, which therefore affects risk assessments of these compounds. However, there is not a direct chemical method to predict the toxicity of ionizable organic compounds. To determine whether hollow-fiber liquid-phase microextraction (HF-LPME) is applicable for this purpose, a three-phase HF-LPME was used to measure sulfadiazine and estimate its toxicity to Daphnia magna in solutions of different pH. The result indicated that the sulfadiazine concentrations measured by HF-LPME decreased with increasing pH, which is consistent with the decreased toxicity. The concentration immobilize 50% of the daphnids (EC50) in 48 h calculated from nominal concentrations increased from 11.93 to 273.5 mg L−1 as the pH increased from 6.0 to 8.5, and the coefficient of variation (CV) of the EC50 values reached 104.6%. When calculated from the concentrations measured by HF-LPME (pH 12 acceptor phase), the EC50 ranged from 223.4 to 394.6 mg L−1, and the CV decreased to 27.60%, suggesting that the concentrations measured by HF-LPME can be used to estimate the toxicity of sulfadiazine irrespective of the solution pH.
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影响因子：
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作者：
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影响因子：
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DOI：
10.1007/s00244-009-9329-4
发表时间：
2010-01-01
影响因子：
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作者：
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通讯作者：
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