High Levels of Soluble Lectin-Like Oxidized Low-Density Lipoprotein Receptor-1 in Acute Stroke: An Age- and Sex-Matched Cross-Sectional Study.
High Levels of Soluble Lectin-Like Oxidized Low-Density Lipoprotein Receptor-1 in Acute Stroke: An Age- and Sex-Matched Cross-Sectional Study.
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DOI：
10.5551/jat.32466
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发表时间：
2016-10-01
影响因子：
4.4
通讯作者：
Minematsu K
中科院分区：
文献类型：
--
作者：
Yokota C;Sawamura T;Watanabe M;Kokubo Y;Fujita Y;Kakino A;Nakai M;Toyoda K;Miyamoto Y;Minematsu K
目的：凝集素样氧化低密度脂蛋白受体-1 （LOX-1）是动脉粥样硬化发病的关键分子。虽然在急性冠状动脉综合征患者中发现了高水平的血清可溶性LOX-1 (sLOX-1)，但没有关于急性卒中患者的报道。本研究的目的是根据不同的脑卒中亚型评估急性脑卒中患者中sLOX-1的水平。方法：我们共纳入377例脑卒中患者（男/女：251/126；年龄：40-79岁），250例缺血性脑卒中和127例脑出血（ICH）患者。患者在中风发作后3天内入院。作为对照，我们从Suita研究的社区队列中根据卒中亚型随机选择年龄和性别匹配且无心血管疾病病史的受试者。根据脑卒中亚型，比较脑卒中患者与健康对照组血清LOX-1水平。结果：脑卒中患者血清sLOX-1的中位数明显高于对照组（缺血性脑卒中患者分别为526 vs 486 ng/L，脑出血患者分别为720 vs 513 ng/L）。在缺血性脑卒中亚型中，只有动脉粥样硬化性血栓性脑梗死患者中位sLOX-1水平（641 ng/L）显著高于对照组（496 ng/L）。缺血性卒中[优势比（OR）， 3.80；经多因素logistic回归分析，95%可信区间（CI） 1.86 ~ 7.74]和ICH （OR, 5.97; 95% CI, 2.13 ~ 16.77）与高水平的sLOX-1独立相关。结论：急性卒中患者的sLOX-1水平高于对照组。高水平的sLOX-1可作为急性卒中的生物标志物。
Aim: Lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) is known to be a key molecule in the pathogenesis of atherosclerosis. Although high levels of serum soluble LOX-1 (sLOX-1) were demonstrated in patients with acute coronary syndrome, there are no reports about acute stroke patients. The aim of the present study was to evaluate the levels of sLOX-1 in acute stroke patients according to different stroke subtypes. Methods: We enrolled a total of 377 patients with a stroke (men/women: 251/126; age: 40–79 years), 250 with ischemic stroke and 127 with intracerebral hemorrhage (ICH). Patients were admitted to our hospital within 3 days after the onset of stroke. As controls, we randomly selected age- and sex-matched subjects without a past history of cardiovascular disease according to stroke subtype from the community-based cohort of the Suita study. Serum LOX-1 levels were compared between stroke patients and healthy controls according to stroke subtype. Results: Median values of serum sLOX-1 in stroke patients were significantly higher than those in controls (526 vs. 486 ng/L in ischemic stroke and 720 vs. 513 ng/L in ICH, respectively). Among subtypes of ischemic stroke, median sLOX-1 levels in atherothrombotic brain infarction (641 ng/L) only were significantly higher than those in controls (496 ng/L). Ischemic stroke [odds ratio (OR), 3.80; 95% confidence interval (CI), 1.86–7.74] and ICH (OR, 5.97; 95% CI, 2.13–16.77) were independently associated with high levels of sLOX-1 by multivariate logistic regression analysis. Conclusions: Higher levels of sLOX-1 were observed in patients with acute stoke than in controls. High levels of sLOX-1 can be useful as biomarker for acute stroke.
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影响因子：
2.4
作者：
Saito, Atsushi;Fujimura, Miki;Tominaga, Teiji
通讯作者：
Tominaga, Teiji
影响因子：
8.7
作者：
Li, DY;Mehta, JL
通讯作者：
Mehta, JL
影响因子：
37.8
作者：
Li, DY;Liu, L;Mehta, JL
通讯作者：
Mehta, JL
LOX-1在高血压诱导的神经细胞凋亡中的新作用
DOI：
10.1016/j.bbrc.2012.07.143
发表时间：
2012-09-07
影响因子：
3.1
作者：
Li, Yali;Duan, Zongming;Niu, Xiaolin
通讯作者：
Niu, Xiaolin
DOI：
10.1073/pnas.95.16.9535
发表时间：
1998-08-04
影响因子：
11.1
作者：
Oka, K;Sawamura, T;Masaki, T
通讯作者：
Masaki, T