Functional imaging of the interaction between gut microbiota and the human host: A proof-of-concept clinical study evaluating novel use for 18F-FDG PET-CT.
Functional imaging of the interaction between gut microbiota and the human host: A proof-of-concept clinical study evaluating novel use for 18F-FDG PET-CT.
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DOI：
10.1371/journal.pone.0192747
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发表时间：
2018
期刊：
影响因子：
3.7
通讯作者：
Yang YX
中科院分区：
文献类型：
--
作者：
Boursi B;Werner TJ;Gholami S;Houshmand S;Mamtani R;Lewis JD;Wu GD;Alavi A;Yang YX
最近比较无菌小鼠与常规饲养小鼠的数据表明，结肠细胞的能量稳态通过调节短链脂肪酸（SCFA）产生和葡萄糖利用而依赖于肠道微生物群。我们试图评估18F-FDG PET-CT作为一种新的技术，用于葡萄糖代谢改变的功能成像，这是肠道微生物群和人类宿主之间相互作用的结果。我们在健康人群中进行了一项前瞻性研究，在口服广谱抗生素之前和之后进行了18F-FDG PET-CT和肠道微生物群采样。主要结局是总的和局部生理性结肠18F-FDG摄取（测量为平均和最大标准化摄取值[SUV平均值和SUV最大值]）。该研究表明，在抗生素治疗后，所有研究参与者的生理性结肠18F-FDG摄取显著增加，肠道细菌负荷减少4-5log。SUVmax的平均增加为0.63±0.37 SD（p = 0.004），中位增加为0.42，IQR为0.40-0.81。SUV平均值的平均增加为0.31±0.24 SD（p = 0.01），中位增加为0.41，IQR为0.06-0.55。这种现象的一个可能的解释是由于SCFA的短缺，结肠细胞代谢向糖酵解的转变。
Recent data comparing germ-free to conventionally-raised mice demonstrated that energy homeostasis of colonocytes is dependent on gut microbiota through regulation of short chain fatty acids (SCFA) production and glucose utilization. We sought to evaluate 18F-FDG PET-CT as a novel technique for functional imaging of alterations in glucose metabolism as a result of the interaction between the gut microbiota and the human host. We conducted a prospective study in healthy humans that underwent 18F-FDG PET-CT and sampling of the gut microbiota before and after orally administered broad-spectrum antibiotics. The primary outcomes were total and regional physiologic colonic 18F-FDG uptake (measured as the mean and max standardized uptake values [SUVmean and SUVmax]). The study demonstrated significant increases in physiologic colonic 18F-FDG uptake in all study participants following antibiotic treatment and a 4-5log reduction of gut bacterial load. The mean increase in SUVmax was 0.63±0.37 SD (p = 0.004) and the median increase was 0.42 with an IQR of 0.40–0.81. The mean increase in SUVmean was 0.31±0.24 SD (p = 0.01) and the median increase was 0.41 with an IQR of 0.06–0.55. A likely explanation for this phenomenon is a shift in colonocyte metabolism to glycolysis due to a shortage of SCFA.
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影响因子：
19.7
作者：
Tatlidil, R;Jadvar, H;Conti, PS
通讯作者：
Conti, PS
影响因子：
3.7
作者：
Ghosh SS;Bie J;Wang J;Ghosh S
通讯作者：
Ghosh S
影响因子：
24.5
作者：
ROEDIGER, WEW
通讯作者：
ROEDIGER, WEW
DOI：
10.1007/s00259-009-1330-7
发表时间：
2010-05-01
影响因子：
9.1
作者：
Ozulker, Tamer;Ozulker, Filiz;Ozpacaci, Tevfik
通讯作者：
Ozpacaci, Tevfik
影响因子：
3.7
作者：
Sobhani I;Tap J;Roudot-Thoraval F;Roperch JP;Letulle S;Langella P;Corthier G;Tran Van Nhieu J;Furet JP
通讯作者：
Furet JP