Human papillomavirus infection and oral squamous cell carcinoma - a systematic review.
Human papillomavirus infection and oral squamous cell carcinoma - a systematic review.
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DOI：
10.1016/j.bjorl.2020.10.017
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发表时间：
2021-05
影响因子：
2.2
通讯作者：
Pereira, Michele Conceicao
中科院分区：
文献类型：
--
作者：
de Carvalho Melo, Bernardo Augusto;Vilar, Luisa Gallo;de Oliveira, Natalia Rodrigues;de Lima, Priscila Oliveira;Pinheiro, Melina de Barros;Domingueti, Caroline Pereira;Pereira, Michele Conceicao
子宫颈和肛门生殖器癌与人乳头瘤病毒（HPV）之间的关系已经得到了很好的证实，但是这种病毒在口腔鳞状细胞癌发展中的作用仍然存在争议。评估HPV感染与口腔鳞状细胞癌之间的关系，并估计这些患者中这种感染的发生率。检索了四个电子数据库，以找到符合以下纳入标准的研究：i)在人类中进行的研究；Ii)队列、病例对照或横断面研究；iii)通过E6和E7 mRNA评估HPV的致癌活性；Iv)包括原发性口腔鳞状细胞癌，其中；V)活检证实诊断。国家信息；研究期间;样本取得;口腔鳞状细胞癌的部位；人口数量、性别、年龄；HPV感染的流行程度和检测到的亚型；排除吸烟或饮酒和口交行为。纳入文献的方法学质量采用14项标准进行评估。搜索策略检索了2129篇文章。对626篇文章的全文进行了评估，但其中5篇被纳入。总共有383名参与者，其中大多数是男性，平均年龄在51.0岁到63.5岁之间。17例患者HPV/ mrna阳性，其中16和18亚型检测频率更高。9例HPV/ mrna阳性口腔鳞状细胞癌发生在舌头上。纳入文章的质量得分平均值为5分。在纳入的383例口腔鳞状细胞癌患者中，17例（4.4%）为HPV/ mrna阳性，然而无法评估HPV感染是否与口腔鳞状细胞癌相关，因为纳入的研究均为纵向和横断面调查，没有对照组。
The association between uterine cervix and anogenital carcinomas and human papillomavirus, HPV, is well established, however the involvement of this virus in the development of oral squamous cell carcinomas remains controversial. To evaluate the relationship between HPV infection and oral squamous cell carcinomas, and to estimate the incidence of this infection in these patients. Four electronic databases were searched to find studies that met the following inclusion criteria: i) performed in humans; ii) were cohort, case-control or cross-sectional; iii) assessed the HPV oncogenic activity by the E6 and E7 mRNA; iv) included primary oral squamous cell carcinomas which; v) diagnosis had been confirmed by biopsy. Information about the country; study period; sample obtainment; sites of oral squamous cell carcinomas; number, gender and age range of the population; the prevalence of HPV infection and subtypes detected; use of tobacco or alcohol and oral sex practice were extracted. The methodological quality of included articles was assessed using 14 criteria. The search strategy retrieved 2129 articles. Assessment of the full text was done for 626 articles, but five were included. The total of participants included was 383, most of them male with mean age between 51.0 and 63.5 years old. Seventeen patients were HPV/mRNA-positive, being the subtypes 16 and 18 detected more frequently. Nine of the HPV/mRNA-positive oral squamous cell carcinomas occurred on the tongue. The quality score average of included articles was five points. Among the 383 oral squamous cell carcinoma patients included, 17 (4.4%) were HPV/mRNA-positive, nevertheless it was not possible to assess if HPV infection was associated with oral squamous cell carcinomas because none of the studies included was longitudinal and cross-sectional investigations do not have control group.
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DOI：
10.1136/bmj.b2535
发表时间：
2009-07-21
期刊：
BMJ (Clinical research ed.)
影响因子：
--
作者：
Moher D;Liberati A;Tetzlaff J;Altman DG;PRISMA Group
通讯作者：
PRISMA Group
影响因子：
7.5
作者：
Bouda, M;Gorgoulis, VG;Kittas, C
通讯作者：
Kittas, C
影响因子：
6.2
作者：
Sturgis, Erich M.;Cinciripini, Paul M.
通讯作者：
Cinciripini, Paul M.
影响因子：
12.7
作者：
Chor, Josette S. Y.;Vlantis, Alexander C.;Chan, Paul K. S.
通讯作者：
Chan, Paul K. S.
影响因子：
3.6
作者：
Reyes, Montserrat;Rojas-Alcayaga, Gonzalo;Aguayo, Francisco
通讯作者：
Aguayo, Francisco