Microenvironment Imbalance of Spinal Cord Injury.
Microenvironment Imbalance of Spinal Cord Injury.
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DOI：
10.1177/0963689718755778
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发表时间：
2018-06
影响因子：
3.3
通讯作者：
Feng S
中科院分区：
文献类型：
--
作者：
Fan B;Wei Z;Yao X;Shi G;Cheng X;Zhou X;Zhou H;Ning G;Kong X;Feng S
脊髓损伤（SCI），目前还没有治愈，是一个沉重的负担，对病人的生理和心理。脊髓损伤的微环境是复杂的。根据我们以往的工作和SCI研究的进展，“微环境失衡”是SCI再生和恢复不良的主要原因。微环境失衡是指组织、细胞和分子在不同时间和空间的抑制因子增加，促进因子减少。在组织水平存在出血与缺血失衡、胶质瘢痕形成、脱髓鞘与髓鞘再生。细胞水平的不平衡涉及内源性干细胞的分化以及小胶质细胞和巨噬细胞的转化表型的不平衡。分子水平包括神经营养因子及其前肽、细胞因子和趋化因子的失衡。脊髓微环境的不平衡损害了再生和功能恢复。这篇综述将有助于理解SCI的病理过程和发展SCI的综合治疗。
Spinal cord injury (SCI), for which there currently is no cure, is a heavy burden on patient physiology and psychology. The microenvironment of the injured spinal cord is complicated. According to our previous work and the advancements in SCI research, ‘microenvironment imbalance’ is the main cause of the poor regeneration and recovery of SCI. Microenvironment imbalance is defined as an increase in inhibitory factors and decrease in promoting factors for tissues, cells and molecules at different times and spaces. There are imbalance of hemorrhage and ischemia, glial scar formation, demyelination and re-myelination at the tissue’s level. The cellular level imbalance involves an imbalance in the differentiation of endogenous stem cells and the transformation phenotypes of microglia and macrophages. The molecular level includes an imbalance of neurotrophic factors and their pro-peptides, cytokines, and chemokines. The imbalanced microenvironment of the spinal cord impairs regeneration and functional recovery. This review will aid in the understanding of the pathological processes involved in and the development of comprehensive treatments for SCI.
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