Maternal Supply of Both Arachidonic and Docosahexaenoic Acids Is Required for Optimal Neurodevelopment.
Maternal Supply of Both Arachidonic and Docosahexaenoic Acids Is Required for Optimal Neurodevelopment.
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DOI：
10.3390/nu13062061
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发表时间：
2021-06-16
期刊：
影响因子：
5.9
通讯作者：
Duttaroy AK
中科院分区：
文献类型：
--
作者：
Basak S;Mallick R;Banerjee A;Pathak S;Duttaroy AK
在妊娠的最后三个月和出生后的头18个月，二十二碳六烯酸(DHA)和花生四烯酸(ARA)都以较快的速度优先沉积在大脑皮质中。虽然DHA在大脑发育中的结构和功能作用已经被很好地研究了，但类似的ARA作用还没有很好的文献记载。这两种脂肪酸及其衍生物在不同结构-功能作用下的作用方式以及它们在大脑基因表达和信号通路中的水平一直在不断地被释放。除了DHA，近年来ARA对胎儿和出生后大脑发育以及母体供应ARA和DHA的重要性也有很多讨论。这些脂肪酸也参与了大脑的各种发育过程；然而，它们的相互作用机制还不清楚。这篇综述描述了除了DHA之外，ARA在支持大脑的最佳发育和生长以及在大脑中的功能作用方面的重要性。
During the last trimester of gestation and for the first 18 months after birth, both docosahexaenoic acid,22:6n-3 (DHA) and arachidonic acid,20:4n-6 (ARA) are preferentially deposited within the cerebral cortex at a rapid rate. Although the structural and functional roles of DHA in brain development are well investigated, similar roles of ARA are not well documented. The mode of action of these two fatty acids and their derivatives at different structural–functional roles and their levels in the gene expression and signaling pathways of the brain have been continuously emanating. In addition to DHA, the importance of ARA has been much discussed in recent years for fetal and postnatal brain development and the maternal supply of ARA and DHA. These fatty acids are also involved in various brain developmental processes; however, their mechanistic cross talks are not clearly known yet. This review describes the importance of ARA, in addition to DHA, in supporting the optimal brain development and growth and functional roles in the brain.
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营养中的Docosahexaenoic酸信号脂肪组学：衰老，神经炎症，黄斑变性，阿尔茨海默氏症和其他神经退行性疾病的重要性。
影响因子：
8.9
作者：
Bazan NG;Molina MF;Gordon WC
通讯作者：
Gordon WC
DOI：
10.3945/ajcn.2009.27580
发表时间：
2009-08
期刊：
The American journal of clinical nutrition
影响因子：
--
作者：
Albanese E;Dangour AD;Uauy R;Acosta D;Guerra M;Guerra SS;Huang Y;Jacob KS;de Rodriguez JL;Noriega LH;Salas A;Sosa AL;Sousa RM;Williams J;Ferri CP;Prince MJ
通讯作者：
Prince MJ
影响因子：
--
作者：
Amminger, G. Paul;Schafer, Miriam R.;Berger, Gregor E.
通讯作者：
Berger, Gregor E.
影响因子：
3.4
作者：
Angelova, Plamena R.;Mueller, Wolfgang S.
通讯作者：
Mueller, Wolfgang S.
影响因子：
6.5
作者：
Aïd, S;Vancassel, S;Lavialle, M
通讯作者：
Lavialle, M