The Staphylococcus aureus RNome and its commitment to virulence.

The Staphylococcus aureus RNome and its commitment to virulence.
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DOI:
10.1371/journal.ppat.1002006
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发表时间:
2011-03
期刊:
影响因子:
6.7
通讯作者:
Romby P
Romby P
中科院分区:
医学1区
文献类型:
--
作者:
Felden B;Vandenesch F;Bouloc P;Romby P

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Staphylococcus aureus is a major human pathogen causing a wide spectrum of nosocomial and community-associated infections with high morbidity and mortality. S. aureus generates a large number of virulence factors whose timing and expression levels are precisely tuned by regulatory proteins and RNAs. The aptitude of bacteria to use RNAs to rapidly modify gene expression, including virulence factors in response to stress or environmental changes, and to survive in a host is an evolving concept. Here, we focus on the recently inventoried S. aureus regulatory RNAs, with emphasis on those with identified functions, two of which are directly involved in pathogenicity.
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