Rapid vigilance and episodic memory decrements in COVID-19 survivors.
Rapid vigilance and episodic memory decrements in COVID-19 survivors.
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DOI：
10.1093/braincomms/fcab295
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发表时间：
2022
影响因子：
4.8
通讯作者：
Husain M
中科院分区：
文献类型：
--
作者：
Zhao S;Shibata K;Hellyer PJ;Trender W;Manohar S;Hampshire A;Husain M
最近的研究表明，COVID-19感染可在一小部分个体中导致严重的神经系统后果。然而，在急性疾病后的几个月里，更多的人会出现疲劳、动力不足、情绪不安、睡眠不佳和认知症状，俗称“脑雾”。但是那些没有症状到中度COVID-19并且在COVID-19康复后没有报告任何担忧的人呢？在这里，我们研究了之前患有COVID-19的人的各种日常生活至关重要的认知功能（包括持续注意力、记忆、运动控制、计划、语义推理、心理旋转和空间视觉注意力），但在自我报告的疲劳、健忘、睡眠异常、动机、抑郁、焦虑和人格特征方面与对照组没有显著差异。令人欣慰的是，COVID-19幸存者在大多数能力测试中表现良好，包括工作记忆、执行功能、计划和心理旋转。然而，他们表现出明显更差的情景记忆（感染后6个月）和更大的警觉性下降随着任务的时间（长达9个月）。总体而言，结果表明，在客观测试中，即使在那些没有报告更大症状负担的人中，COVID-19后的特定慢性认知变化也很明显。重要的是，在这里测试的样本中，这些在6-9个月后与正常情况没有显着差异，表明随着时间的推移有恢复的证据。Zhao等人报道，与年龄匹配的对照组相比，无症状至中度COVID-19的COVID-19幸存者表现出更快的警惕性下降和更差的情景记忆。令人放心的是，差异在6-9个月后消失，显示出随时间恢复的证据。
Recent studies indicate that COVID-19 infection can lead to serious neurological consequences in a small percentage of individuals. However, in the months following acute illness, many more suffer from fatigue, low motivation, disturbed mood, poor sleep and cognitive symptoms, colloquially referred to as ‘brain fog’. But what about individuals who had asymptomatic to moderate COVID-19 and reported no concerns after recovering from COVID-19? Here, we examined a wide range of cognitive functions critical for daily life (including sustained attention, memory, motor control, planning, semantic reasoning, mental rotation and spatial–visual attention) in people who had previously suffered from COVID-19 but were not significantly different from a control group on self-reported fatigue, forgetfulness, sleep abnormality, motivation, depression, anxiety and personality profile. Reassuringly, COVID-19 survivors performed well in most abilities tested, including working memory, executive function, planning and mental rotation. However, they displayed significantly worse episodic memory (up to 6 months post-infection) and greater decline in vigilance with time on task (for up to 9 months). Overall, the results show that specific chronic cognitive changes following COVID-19 are evident on objective testing even amongst those who do not report a greater symptom burden. Importantly, in the sample tested here, these were not significantly different from normal after 6–9 months, demonstrating evidence of recovery over time. Zhao et al. reported COVID-19 survivors who had asymptomatic to moderate COVID-19 showed a faster decline in vigilance and worse episodic memory compared with the age-matched controls. Reassuringly, the differences disappear after 6–9 months demonstrating evidence of recovery over time.
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DOI：
10.2967/jnumed.121.262128
发表时间：
2021-07-01
期刊：
Journal of nuclear medicine : official publication, Society of Nuclear Medicine
影响因子：
--
作者：
Blazhenets G;Schroeter N;Bormann T;Thurow J;Wagner D;Frings L;Weiller C;Meyer PT;Dressing A;Hosp JA
通讯作者：
Hosp JA
影响因子：
3.3
作者：
Ferrucci R;Dini M;Groppo E;Rosci C;Reitano MR;Bai F;Poletti B;Brugnera A;Silani V;D'Arminio Monforte A;Priori A
通讯作者：
Priori A
影响因子：
15.1
作者：
Hampshire A;Trender W;Chamberlain SR;Jolly AE;Grant JE;Patrick F;Mazibuko N;Williams SC;Barnby JM;Hellyer P;Mehta MA
通讯作者：
Mehta MA
影响因子：
14.5
作者：
Hosp, Jonas A.;Dressing, Andrea;Meyer, Philipp T.
通讯作者：
Meyer, Philipp T.
影响因子：
3.4
作者：
Duckworth, Angela Lee;Quinn, Patrick D.
通讯作者：
Quinn, Patrick D.