The hippocampus is critical for spatial relational attention
The hippocampus is critical for spatial relational attention
复制标题
海马体对于空间关系注意力至关重要
DOI：
--
复制
发表时间：
2019
期刊：
影响因子：
--
通讯作者：
Mariam Aly
中科院分区：
文献类型：
--
作者：
Nicholas A. Ruiz;Michael R. Meager;Sachin Agarwal;Mariam Aly
海马体传统上被认为是一个专门用于长期记忆的系统。最近的研究对这一观点提出了挑战，证明该区域可以对长期记忆以外的许多认知领域做出贡献，包括感知和注意力。海马体对认知有广泛贡献的一个潜在原因是，它包含了关系表征--经验的多维特征的表征--这些表征在许多不同的认知领域都很有用。在这里，我们探讨的假设，海马通过其关系表征在注意中起着至关重要的作用。我们比较了海马损伤的人类参与者与健康的年龄和教育匹配的个体在注意力任务中的关系处理的类型和数量不同。在每次试验中，参与者观看两张图片（有绘画的房间）。在房间关系试验中，他们从不同的角度判断房间是否具有相同的空间布局。在艺术关系试验中，他们判断这些画是否可能是同一位艺术家画的。对照试验对关系处理的要求较少：参与者只需检测相同的绘画或房间。海马损伤的患者在空间关系任务上明显受损。选择性海马损伤与更广泛的内侧颞叶损伤的效果相当，这表明海马本身在空间关系注意中起着关键作用。这项工作提供了进一步的证据表明，海马体在认知中发挥着无处不在的作用，凭借其关系表示，并强调空间关系可能是特别重要的。人类海马主要是研究其在长期记忆中的作用，但最近的工作表明，它可能对认知的许多方面都有广泛的贡献。在这里，我们测试海马是否凭借其灵活的关系和空间表征在视觉注意中起着至关重要的作用。海马损伤的患者在需要注意空间关系的任务中明显受损。这些结果突出了海马对认知的普遍贡献，包括在线视觉注意。
The hippocampus is traditionally considered to be a system that is specialized for long-term memory. Recent work has challenged this notion by demonstrating that this region can contribute to many domains of cognition beyond long-term memory, including perception and attention. One potential reason why the hippocampus contributes broadly to cognition is that it contains relational representations — representations of muli-dimensional features of experience — that are useful in many different cognitive domains. Here, we explore the hypothesis that the hippocampus plays a critical role in attention via its relational representations. We compared human participants with hippocampal damage to healthy age- and education-matched individuals on attention tasks that varied in the type and amount of relational processing required. On each trial, participants viewed two images (rooms with paintings). On room relational trials, they judged whether the rooms had the same spatial layout from a different perspective. On art relational trials, they judged whether the paintings could have been painted by the same artist. Control trials placed fewer demands on relational processing: Participants simply had to detect identical paintings or rooms. Patients with hippocampal damage were significantly impaired on the room relational task. Selective hippocampal lesions had comparable effects to more extensive medial temporal lobe damage, suggesting that the hippocampus itself plays a critical role in spatial relational attention. This work provides further evidence that the hippocampus plays a ubiquitous role in cognition by virtue of its relational representations, and highlights that spatial relations may be particularly important. Significance statement The human hippocampus is primarily studied for its role in long-term memory, but recent work suggests that it may contribute broadly to many aspects of cognition. Here, we test whether the hippocampus plays a critical role in visual attention by virtue of its flexible relational and spatial representations. Patients with hippocampal damage were significantly impaired on a task that required attention to spatial relations. These results highlight the ubiquity of hippocampal contributions to cognition, including online visual attention.
登录
查看更多内容
网络范围的异常解释了海马失忆症的记忆变异性
DOI：
10.1101/551812
发表时间：
2019
期刊：
--
影响因子：
--
作者：
Argyropoulos G
通讯作者：
Argyropoulos G
影响因子：
3.7
作者：
Aly, Mariam;Turk-Browne, Nicholas B.
通讯作者：
Turk-Browne, Nicholas B.
影响因子：
4.1
作者：
Shohamy, Daphna;Turk-Browne, Nicholas B.
通讯作者：
Turk-Browne, Nicholas B.
影响因子：
13.9
作者：
Squire LR;Wixted JT
通讯作者：
Wixted JT