Synthesis, characterization and evaluation of azobenzene nanogels for their antibacterial properties in adhesive dentistry.
Synthesis, characterization and evaluation of azobenzene nanogels for their antibacterial properties in adhesive dentistry.
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DOI：
10.1111/eos.12832
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发表时间：
2022-03
影响因子：
1.9
通讯作者：
Nair DP
中科院分区：
文献类型：
--
作者：
Trivedi R;Gautam D;Kehe GM;Escobedo HD;Patel K;Stansbury JW;Schurr MJ;Nair DP
致龋菌在预备好的牙洞内存在于粘结树脂-牙本质界面处，这对复合材料的长期稳定性和功能是有害的。在这里，我们报告的合成和纳入双酚A-甲基丙烯酸缩水甘油酯/甲基丙烯酸羟乙酯/乙醇（B/H/E）粘合剂树脂的甲基丙烯酸偶氮苯纳米凝胶和评估其能力，以减少致龋变形链球菌生物膜的细菌入侵，同时保持修复体和牙齿之间的关键界面连接的机械强度和结构完整性。将流体动力学半径< 2 nm且分子量为12，000 Da的偶氮苯纳米凝胶在B/H/E粘合剂制剂中以0.5重量%的浓度聚合，1.5重量百分比，和2.5重量%。虽然粘合剂网络的双键转化、细胞相容性、水溶性和吸附相当，但偶氮苯纳米凝胶网络显示出改善的疏水性，水接触角增加≥ 25°。用偶氮苯纳米凝胶配制的聚合粘合剂表面显示出相对于对照的细菌生物膜减少66%，同时保持粘合剂网络的机械性能和微拉伸粘合强度。增加的疏水性和抗菌活性是有希望的指标，表明偶氮苯纳米凝胶添加剂具有增加粘合剂树脂的耐久性和寿命的潜力。
The presence of cariogenic bacteria within the prepared tooth cavity at the adhesive resin-dentin interface is detrimental to the long-term stability and function of composite restorations. Here, we report the synthesis and incorporation of methacrylated azobenzene nanogels within bisphenol A-glycidyl methacrylate/hydroxyethyl methacrylate/ethanol (B/H/E) adhesive resins and evaluate their ability to reduce the bacterial invasion of cariogenic Streptococcus mutans biofilms while preserving the mechanical strength and structural integrity of the critical interfacial connection between the restoration and the tooth. The azobenzene nanogel, with a hydrodynamic radius of < 2 nm and a molecular weight of 12,000 Da, was polymerized within B/H/E adhesive formulations at concentrations of 0.5 wt.%, 1.5 wt.%, and 2.5 wt.%. While the double-bond conversion, cytocompatibility, water solubility, and sorption of the adhesive networks were comparable, azobenzene nanogel networks showed improved hydrophobicity with a ≥ 25° increase in water contact angle. The polymerized adhesive surfaces formulated with azobenzene nanogels showed a 66% reduction in bacterial biofilms relative to the control while maintaining the mechanical properties and micro-tensile bond strength of the adhesive networks. The increased hydrophobicity and antibacterial activity are promising indicators that azobenzene nanogel additives have the potential to increase the durability and longevity of adhesive resins.
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DOI：
10.3390/molecules22060875
发表时间：
2017-05-25
期刊：
Molecules (Basel, Switzerland)
影响因子：
--
作者：
Concilio S;Sessa L;Petrone AM;Porta A;Diana R;Iannelli P;Piotto S
通讯作者：
Piotto S
影响因子：
2.1
作者：
Cardoso, M. V.;Neves, A. de Almeida;Van Meerbeek, B.
通讯作者：
Van Meerbeek, B.
影响因子：
3.2
作者：
Kreth, Jens;Zhang, Yongshu;Herzberg, Mark C.
通讯作者：
Herzberg, Mark C.
影响因子：
5
作者：
Song, Linyong;Sarikaya, Rizacan;Spencer, Paulette
通讯作者：
Spencer, Paulette
影响因子：
9.5
作者：
Kehe, Gannon M.;Mori, Dylan I.;Nair, Devatha P.
通讯作者：
Nair, Devatha P.