Role of mineralocorticoid receptors in arterial stiffness in human aging.
Role of mineralocorticoid receptors in arterial stiffness in human aging.
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DOI：
10.1016/j.exger.2013.05.058
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发表时间：
2013-08
影响因子：
3.9
通讯作者：
Christou, Demetra D.
中科院分区：
文献类型：
--
作者：
Hwang, Moon-Hyon;Yoo, Jeung-Ki;Luttrell, Meredith;Kim, Han-Kyul;Meade, Thomas H.;English, Mark;Nichols, Wilmer W.;Christou, Demetra D.
动脉僵硬度是心血管疾病的独立预测因子，随着年龄的增长而增加，但其潜在机制尚未完全了解。盐皮质激素受体（MR）可能导致健康老年人的氧化应激和动脉硬化。为了检验短期MR阻断剂可以降低氧化应激和改善动脉僵硬度的假设，我们在23名无明显心血管和其他临床疾病（如糖尿病、肾脏和肝脏疾病）的老年人（年龄，64±1岁;平均值±SE）中使用选择性MR阻断剂依普利酮或安慰剂进行了一项随机、双盲、交叉研究。MR阻滞后，肱动脉和颈动脉血压下降（P≤0.01）。然而，MR阻断对氧化应激没有影响（氧化LDL，61.2±6.8 vs. 62.4±7.4 U/L，P=0.9;安慰剂vs.依普利酮）和动脉僵硬度（主动脉脉搏波速度（PWV）为9.17±1.19 m/sec，下肢PWV为13.45±0.45 m/sec，下肢PWV为12.81±0.47 m/sec，P=0.3;臂PWV，11.43±0.62 vs. 11.73±0.68 m/sec，P=0.7;颈动脉顺应性，0.150±0.013 vs. 0.149±0.014 mm 2/mmHg，P=0.8;扩张性，23.1±1.8 vs. 23.3±1.7 10−3/kPa，P=0.8; β硬度指数，3.5±0.3 vs. 3.6±0.3，P=0.6;增强指数，16.0±2.2 vs. 15.6± 2.8%，P=0.8）。这些结果提供了第一个证据，表明MR似乎不会导致人类衰老中的氧化应激，并且短期MR阻断不会导致氧化应激降低和动脉僵硬度改善。
Arterial stiffness, an independent predictor of cardiovascular disease, is increased in aging, but the underlying mechanisms are not completely understood. Mineralocorticoid receptors (MR) may contribute to oxidative stress and arterial stiffness in healthy older adults. To test the hypothesis that short-term MR blockade may reduce oxidative stress and improve arterial stiffness, we conducted a randomized, double blind, crossover study using the selective MR blocker Eplerenone or placebo in 23 older adults (age, 64±1 years; mean±SE) free from overt cardiovascular and other clinical disease (e.g, diabetes, renal and liver disease). In response to MR blockade, brachial and carotid blood pressure decreased (P≤0.01). However, MR blockade had no effect on oxidative stress (oxidized LDL, 61.2±6.8 vs. 62.4±7.4 U/L, P=0.9; placebo vs. Eplerenone) and arterial stiffness (aortic pulse wave velocity (PWV), 9.17±1.19 vs. 8.92±1.19 m/sec, P=0.5; leg PWV, 13.45±0.45 vs. 12.81±0.47 m/sec, P=0.3; arm PWV, 11.43±0.62 vs. 11.73±0.68 m/sec, P=0.7; carotid artery compliance, 0.150±0.013 vs. 0.149±0.014 mm2/mmHg, P=0.8; distensibility, 23.1±1.8 vs. 23.3±1.7 10−3/kPa, P=0.8; β stiffness index, 3.5±0.3 vs. 3.6±0.3, P=0.6; and augmentation index, 16.0±2.2 vs. 15.6±2.8 %, P=0.8). These results provide the first evidence that MR do not appear to contribute to oxidative stress in human aging and that short-term MR blockade does not result in reduced oxidative stress and improved arterial stiffness.
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影响因子：
37.8
作者：
Sutton-Tyrrell, K;Najjar, SS;Newman, A
通讯作者：
Newman, A
影响因子：
37.8
作者：
Keidar, S;Kaplan, M;Aviram, M
通讯作者：
Aviram, M
影响因子：
8.3
作者：
Moreau, KL;Gavin, KM;Seals, DR
通讯作者：
Seals, DR
影响因子：
8.3
作者：
Gates, PE;Tanaka, H;Seals, DR
通讯作者：
Seals, DR
影响因子：
7.8
作者：
Sindler AL;Fleenor BS;Calvert JW;Marshall KD;Zigler ML;Lefer DJ;Seals DR
通讯作者：
Seals DR