Toward a conceptualization of retrohippocampal contributions to learning and memory.
Toward a conceptualization of retrohippocampal contributions to learning and memory.
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DOI：
10.1016/j.nlm.2014.05.007
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发表时间：
2014-12
影响因子：
2.7
通讯作者：
Robinson, Siobhan
中科院分区：
文献类型：
--
作者：
Bucci, David J.;Robinson, Siobhan
大量数据支持海马体在时间和地点将物体和事件联系在一起的观点。为了支持这一功能，包括脾后皮质(RSC)和海马区旁区域的各种结构的皮质回路被认为为海马体提供关于物体/事件发生的物理和时间背景的基本信息。然而，目前还不清楚这个所谓的“哪里”回路的各个组件是否以及如何对处理与上下文相关的信息做出独特的贡献。在这里，我们集中在RSC和纹后皮质(POR；与灵长类动物的海马旁皮质(PHC)同源)，这是WHERE通路中联系最紧密的两个组成部分，也是最近越来越多研究的焦点。到目前为止，许多行为证据表明，RSC和POR/PHC作为一个功能单位密切合作。我们首先简要回顾了研究RSC和POR/PHC参与语境和空间学习的研究，这两个研究都涉及构成环境(即信息所在位置)的个体刺激之间的学习联系和关系。然而，我们认为潜在的差异被忽视了，因为到目前为止的大多数研究都依赖于行为范式和实验方法，这些方法不太适合区分信息处理的不同方面。然后，我们考虑了RSC和POR/PHC之间的解剖学差异，以及新出现的行为证据，这些证据产生了一个工作模型，说明这些区域如何对海马依赖的学习和记忆做出不同的贡献。然后，我们讨论可能对测试该模型有用的实验设计和行为方法。最后，描述了在探索信息处理的本质和嵌套在WHERE通路内的无数局部回路中的神经可塑性方面可能有价值的方法。
A wealth of data supports the notion that the hippocampus binds objects and events together in place and time. In support of this function, a cortical circuit that includes the retrosplenial cortex (RSC) and various structures in the parahippocampal region is thought to provide the hippocampus with essential information regarding the physical and temporal context in which the object/event occurs. However, it remains unclear if and how individual components of this so-called ‘where’ circuit make unique contributions to processing context-related information. Here we focus on the RSC and the postrhinal cortex (POR; homologous with parahippocampal cortex (PHC) in primates), two of the most strongly interconnected components of the where pathway and the foci of an increasing amount of recent research. Much of the behavioral evidence to date suggests that RSC and POR/PHC work closely together as a functional unit. We begin by briefly reviewing studies that have investigated the involvement of RSC and POR/PHC in contextual and spatial learning, both of which involve learning associations and relationships between the individual stimuli that compose an environment (i.e., where information). However, we propose that potential differences have been overlooked because most studies to date have relied on behavioral paradigms and experimental approaches that are not well suited for distinguishing between different aspects of information processing. We then consider the anatomical differences between RSC and POR/PHC and emerging behavioral evidence that gives rise to a working model of how these regions may differentially contribute to hippocampal-dependent learning and memory. We then discuss experimental designs and behavioral methods that may be useful in testing the model. Finally, approaches are described that may be valuable in probing the nature of information processing and neuroplasticity in the myriad of local circuits that are nested within the where pathway.
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DOI：
10.1073/pnas.0700293104
发表时间：
2007-03-20
影响因子：
11.1
作者：
Armbruster, Blaine N.;Li, Xiang;Roth, Bryan L.
通讯作者：
Roth, Bryan L.
影响因子：
1.9
作者：
BAXTER, MG;BUCCI, DJ;GALLAGHER, M
通讯作者：
GALLAGHER, M
影响因子：
1.9
作者：
BUNSEY, M;EICHENBAUM, H
通讯作者：
EICHENBAUM, H
影响因子：
2.7
作者：
Bucci, David J.
通讯作者：
Bucci, David J.
影响因子：
1.9
作者：
Bucci, DJ;Saddoris, MP;Burwell, RD
通讯作者：
Burwell, RD