The association of nonalcoholic fatty liver disease, obesity, and metabolic syndrome, with systemic inflammation and subclinical atherosclerosis: the Multi-Ethnic Study of Atherosclerosis (MESA).
The association of nonalcoholic fatty liver disease, obesity, and metabolic syndrome, with systemic inflammation and subclinical atherosclerosis: the Multi-Ethnic Study of Atherosclerosis (MESA).
复制标题
DOI：
10.1016/j.atherosclerosis.2015.02.011
复制
发表时间：
2015-04
期刊：
影响因子：
5.3
通讯作者：
Blaha, Michael J.
中科院分区：
文献类型：
--
作者：
Al Rifai, Mahmoud;Silverman, Michael G.;Nasir, Khurram;Budoff, Matthew J.;Blankstein, Ron;Szklo, Moyses;Katz, Ronit;Blumenthal, Roger S.;Blaha, Michael J.
关键词：
我们分析了 3 种代谢状况（肥胖、代谢综合征和非酒精性脂肪肝病 (NAFLD)）与炎症增加和亚临床动脉粥样硬化的关联。我们对动脉粥样硬化多种族研究 (MESA) 的 3,976 名参与者进行了横断面分析，并使用足够的 CT 成像来诊断 NAFLD。肥胖被定义为BMI≥30 kg/m2、AHA/NHLBI标准的代谢综合征、以及使用非增强心脏CT的NAFLD和肝/脾衰减比(L/S)<1。炎症增加定义为高敏C反应蛋白（hsCRP）≥2 mg/L，亚临床动脉粥样硬化定义为冠状动脉钙（CAC）>0。我们研究了这些代谢状况 (0-3) 数量的逐步增加与炎症和 CAC 增加的关联，并按性别和种族对结果进行了分层。参与者的平均年龄为 63 (±10) 岁，其中 45% 为男性，37% 为白人，10% 为中国人，30% 为非洲裔美国人，23% 为西班牙裔。调整肥胖、代谢综合征和传统危险因素后，NAFLD 与 hsCRP ≥2 mg/L 和 CAC >0 的患病率比值比分别为 1.47 (1.20–1.79) 和 1.37 (1.11–1.68)。在 hsCRP ≥ 2 mg/L 的情况下，女性与 NAFLD 之间存在正交互作用（p= 0.006），而种族之间没有交互作用。随着代谢状况的增加，hsCRP ≥2 mg/L 和 CAC > 0 的患病率逐渐增加。 NAFLD 与炎症和 CAC 增加相关，与传统危险因素、肥胖和代谢综合征无关。肥胖、代谢综合征和 NAFLD 与炎症和 CAC 之间存在分级关联。
We characterized the association of 3 metabolic conditions – obesity, metabolic syndrome, and nonalcoholic fatty liver disease (NAFLD) – with increased inflammation and subclinical atherosclerosis. We conducted cross-sectional analysis of 3,976 participants from the Multi-Ethnic Study of Atherosclerosis (MESA) with adequate CT imaging to diagnose NAFLD. Obesity was defined as BMI ≥30 kg/m2, metabolic syndrome by AHA/NHLBI criteria, and NAFLD using non-contrast cardiac CT and a liver/spleen attenuation ratio (L/S) <1. Increased inflammation was defined as high sensitivity C-reactive protein (hsCRP) ≥2 mg/L and subclinical atherosclerosis as coronary artery calcium (CAC) >0. We studied the association of a stepwise increase in number of these metabolic conditions (0–3) with increased inflammation and CAC, stratifying results by gender and ethnicity. Mean age of participants was 63 (±10) years, 45% were male, 37% white, 10% Chinese, 30% African American, and 23% Hispanic. Adjusting for obesity, metabolic syndrome and traditional risk factors, NAFLD was associated with a prevalence odds ratio for hsCRP ≥2 mg/L and CAC >0 of 1.47 (1.20–1.79) and 1.37 (1.11–1.68) respectively. There was a positive interaction between female gender and NAFLD in the association with hsCRP ≥2 mg/L (p= 0.006), with no interaction by race. With increasing number of metabolic conditions, there was a graded increase in prevalence odds ratios of hsCRP ≥2 mg/L and CAC >0. NAFLD is associated with increased inflammation and CAC independent of traditional risk factors, obesity and metabolic syndrome. There is a graded association between obesity, metabolic syndrome, and NAFLD with inflammation and CAC.
登录
查看更多内容
非酒精性脂肪肝病与冠状动脉钙化有关。
影响因子：
13.5
作者：
Kim, Donghee;Choi, Su-Yeon;Park, Eun Ha;Lee, Whal;Kang, Jin Hwa;Kim, Won;Kim, Yoon Jun;Yoon, Jung-Hwan;Jeong, Sook Hyang;Lee, Dong Ho;Lee, Hyo-suk;Larson, Joseph;Therneau, Terry M.;Kim, W. Ray
通讯作者：
Kim, W. Ray
影响因子：
7.7
作者：
Targher, G;Bertolini, L;Falezzal, G
通讯作者：
Falezzal, G
影响因子：
5.3
作者：
Liu, Jiankang;Musani, Solomon K.;Fox, Caroline S.
通讯作者：
Fox, Caroline S.
影响因子：
158.5
作者：
Detrano, Robert;Guerci, Alan D.;Kronmal, Richard A.
通讯作者：
Kronmal, Richard A.
DOI：
10.1016/0735-1097(90)90282-t
发表时间：
1990-03-15
影响因子：
24
作者：
AGATSTON, AS;JANOWITZ, WR;DETRANO, R
通讯作者：
DETRANO, R