Learning in Parkinson's disease: eyeblink conditioning, declarative learning, and procedural learning.
Learning in Parkinson's disease: eyeblink conditioning, declarative learning, and procedural learning.
复制标题
帕金森病的学习：眨眼条件反射、陈述性学习和程序性学习。
DOI：
10.1136/jnnp.67.1.27
复制
发表时间：
1999
期刊：
影响因子：
--
通讯作者：
Hallett,M
中科院分区：
文献类型：
--
作者：
Sommer,M;Grafman,J;Clark,K;Hallett,M
目的评价帕金森病患者的学习能力。方法对帕金森病患者和正常（对照）被试进行三种不同的学习任务：延迟和追踪范式的经典条件反射、加利福尼亚语言学习测验（CVLT）和连续反应时间任务（SRTT）。结果在眨眼条件反射任务中，患者和正常受试者均表现出显著的学习效果，组间无差异。在CVLT中，在短期和长期提示回忆任务中，患者记住的单词明显少于正常受试者。在SRTT中，正常受试者的反应时间和错误率显著降低，而患者的反应时间和错误率显著降低，但反应时间率没有显著降低。结论黑质纹状体通路的损伤选择性地影响了SRTT等竞争性和警觉性要求较高的复杂学习任务的表现，而对眨眼条件反射等简单学习过程无影响。
OBJECTIVETo assess the degree of learning ability in Parkinson’s disease.METHODSThree different learning tasks: eyeblink classical conditioning with delay and trace paradigms, the California verbal learning test (CVLT), and a serial reaction time task (SRTT) were studied in patients with Parkinson’s disease and normal (control) subjects.RESULTSIn the eyeblink conditioning tasks, both patients and normal subjects showed significant learning effects without between group differences. In the CVLT, patients remembered significantly fewer words than normal subjects in both short term and long term cued recall tasks. In the SRTT, normal subjects had significantly reduced response time and error rates across blocks of repeated sequence trials, whereas patients had significantly reduced error, but not response time rates.CONCLUSIONImpairment of nigrostriatal pathways selectively affects performance in complex learning tasks that are competitive and require alertness such as the SRTT, but not in simple learning procedures such as eyeblink conditioning.
登录
查看更多内容
影响因子：
--
作者：
COBLENTZ, JM;MATTIS, S;KATZMAN, R
通讯作者：
KATZMAN, R
影响因子：
3.5
作者：
Martin Sommer;G. Wöbker;A. Ferbert
通讯作者：
A. Ferbert
DOI：
10.1073/pnas.92.16.7500
发表时间：
1995-08
影响因子：
11.1
作者：
C. Logan;Scott T. Grafton
通讯作者：
C. Logan;Scott T. Grafton
加强条件的眉毛反应习得和主动干扰焦虑脆弱的个体。
影响因子：
3
作者：
Holloway JL;Trivedi P;Myers CE;Servatius RJ
通讯作者：
Servatius RJ
影响因子：
4.4
作者：
Konagaya, M;Konagaya, Y;Hashizume, Y
通讯作者：
Hashizume, Y