Enhanced conditioned eyeblink response acquisition and proactive interference in anxiety vulnerable individuals.
Enhanced conditioned eyeblink response acquisition and proactive interference in anxiety vulnerable individuals.
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加强条件的眉毛反应习得和主动干扰焦虑脆弱的个体。
DOI：
10.3389/fnbeh.2012.00076
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发表时间：
2012
影响因子：
3
通讯作者：
Servatius RJ
中科院分区：
文献类型：
--
作者：
Holloway JL;Trivedi P;Myers CE;Servatius RJ
在经典条件反射中，前摄干扰可能来自条件刺激（CS）、无条件刺激（US）或两者的经验，在它们配对呈现之前。对主动干预应用的兴趣已经扩展到临床人群，作为疾病的风险因素或次要体征。虽然目前的文献是密集的动物刺激预暴露效果的比较，这种比较是缺乏在人类受试者。因此，对主动干预研究的解释及其在临床研究中的推广和实用性是有限的。本研究的目的是评估眨眼反应收购后，相同数量的CS，US，明确未配对CS和US预曝光，以及评估如何焦虑脆弱性可能会调节积极的干扰。在目前的研究中，焦虑脆弱性进行了评估，使用状态/特质焦虑量表以及成人和回顾性措施的行为抑制（AMBI和RMBI，分别）。参与者暴露于4种可能的预暴露意外事件之一：30 CS，30 US，30 CS和30 US明确未配对预暴露，或在标准延迟训练之前立即进行上下文预暴露。相对于背景预暴露，在所有预暴露组中，稳健的主动干预是明显的，与焦虑分类无关，CR采集以相似的速率衰减。此外，特质焦虑的个人被发现有增强的整体收购，以及更大的主动干预相对于非脆弱的个人。研究结果表明，焦虑脆弱的个人学习内隐协会更快，这种效果仍然存在后，引入新的刺激突发事件。这种影响并不是因为对美国的敏感性增强。这种差异将对学习框架内焦虑心理病理学的发展产生影响。
In classical conditioning, proactive interference may arise from experience with the conditioned stimulus (CS), the unconditional stimulus (US), or both, prior to their paired presentations. Interest in the application of proactive interference has extended to clinical populations as either a risk factor for disorders or as a secondary sign. Although the current literature is dense with comparisons of stimulus pre-exposure effects in animals, such comparisons are lacking in human subjects. As such, interpretation of proactive interference over studies as well as its generalization and utility in clinical research is limited. The present study was designed to assess eyeblink response acquisition after equal numbers of CS, US, and explicitly unpaired CS and US pre-exposures, as well as to evaluate how anxiety vulnerability might modulate proactive interference. In the current study, anxiety vulnerability was assessed using the State/Trait Anxiety Inventories as well as the adult and retrospective measures of behavioral inhibition (AMBI and RMBI, respectively). Participants were exposed to 1 of 4 possible pre-exposure contingencies: 30 CS, 30 US, 30 CS, and 30 US explicitly unpaired pre-exposures, or Context pre-exposure, immediately prior to standard delay training. Robust proactive interference was evident in all pre-exposure groups relative to Context pre-exposure, independent of anxiety classification, with CR acquisition attenuated at similar rates. In addition, trait anxious individuals were found to have enhanced overall acquisition as well as greater proactive interference relative to non-vulnerable individuals. The findings suggest that anxiety vulnerable individuals learn implicit associations faster, an effect which persists after the introduction of new stimulus contingencies. This effect is not due to enhanced sensitivity to the US. Such differences would have implications for the development of anxiety psychopathology within a learning framework.
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影响因子：
1.6
作者：
Beck, Kevin D.;McLaughlin, Joselyn;Servatius, Richard J.
通讯作者：
Servatius, Richard J.
影响因子：
22.4
作者：
LUBOW, RE
通讯作者：
LUBOW, RE
影响因子：
2.7
作者：
Ricart, Thomas M.;De Niear, Matthew A.;Jiao, Xilu;Pang, Kevin C. H.;Beck, Kevin D.;Servatius, Richard J.
通讯作者：
Servatius, Richard J.
影响因子：
11.3
作者：
Gladstone, G;Parker, G
通讯作者：
Parker, G
影响因子：
7.4
作者：
Gladstone, GL;Parker, GB;Malhi, GS
通讯作者：
Malhi, GS