New susceptibility and resistance HLA-DP alleles to HBV-related diseases identified by a trans-ethnic association study in Asia.
New susceptibility and resistance HLA-DP alleles to HBV-related diseases identified by a trans-ethnic association study in Asia.
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DOI：
10.1371/journal.pone.0086449
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发表时间：
2014
期刊：
影响因子：
3.7
通讯作者：
Mizokami M
中科院分区：
文献类型：
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作者：
Nishida N;Sawai H;Kashiwase K;Minami M;Sugiyama M;Seto WK;Yuen MF;Posuwan N;Poovorawan Y;Ahn SH;Han KH;Matsuura K;Tanaka Y;Kurosaki M;Asahina Y;Izumi N;Kang JH;Hige S;Ide T;Yamamoto K;Sakaida I;Murawaki Y;Itoh Y;Tamori A;Orito E;Hiasa Y;Honda M;Kaneko S;Mita E;Suzuki K;Hino K;Tanaka E;Mochida S;Watanabe M;Eguchi Y;Masaki N;Murata K;Korenaga M;Mawatari Y;Ohashi J;Kawashima M;Tokunaga K;Mizokami M
先前的研究已经揭示了位于人类白细胞抗原（HLA）II类基因（包括HLA-DP和HLA-DQ）上的SNP与慢性B型肝炎病毒（HBV）感染（主要在亚洲人群中）之间的关联。在亚洲人群中，与慢性HBV感染或疾病进展相关的HLA-DP等位基因或单倍型尚未完全确定。我们在亚洲人群（包括日本、韩国、香港和泰国受试者）中进行了HLA-DPA 1、HLA-DPB 1等位基因和单倍型与B型肝炎病毒感染和疾病进展的跨种族关联分析。为了评估HLA-DP与慢性HBV感染和疾病进展之间的关联，我们对总共3，167个样本进行了高分辨率（4位数）HLA-DPA 1和HLA-DPB 1基因分型，包括HBV患者，HBV消退个体和健康对照。亚洲人群的跨种族关联分析确定了一个新的风险等位基因HLA-DPB 1 *09∶01（P = 1.36×10−6; OR = 1.97; 95%CI，1.50-2.59）和一个新的保护性等位基因DPB 1 *02∶01（P = 5.22×10−6; OR = 0.68; 95%CI，0.58-0.81），除了以前报道的等位基因。 此外，DPB 1 *02∶01还与亚洲人群中慢性HBV患者疾病进展风险降低相关（P = 1.55×10−7; OR = 0.50; 95%CI，0.39-0.65）。 跨种族关联分析确定了HLA-DP等位基因和单倍型与HBV感染或疾病进展的亚洲特异性关联。本研究结果将为进一步研究HLA-DP分子的功能奠定基础，以了解HBV感染的发病机制和肝细胞癌的发展。
Previous studies have revealed the association between SNPs located on human leukocyte antigen (HLA) class II genes, including HLA-DP and HLA-DQ, and chronic hepatitis B virus (HBV) infection, mainly in Asian populations. HLA-DP alleles or haplotypes associated with chronic HBV infection or disease progression have not been fully identified in Asian populations. We performed trans-ethnic association analyses of HLA-DPA1, HLA-DPB1 alleles and haplotypes with hepatitis B virus infection and disease progression among Asian populations comprising Japanese, Korean, Hong Kong, and Thai subjects. To assess the association between HLA-DP and chronic HBV infection and disease progression, we conducted high-resolution (4-digit) HLA-DPA1 and HLA-DPB1 genotyping in a total of 3,167 samples, including HBV patients, HBV-resolved individuals and healthy controls. Trans-ethnic association analyses among Asian populations identified a new risk allele HLA-DPB1*09∶01 (P = 1.36×10−6; OR = 1.97; 95% CI, 1.50–2.59) and a new protective allele DPB1*02∶01 (P = 5.22×10−6; OR = 0.68; 95% CI, 0.58–0.81) to chronic HBV infection, in addition to the previously reported alleles. Moreover, DPB1*02∶01 was also associated with a decreased risk of disease progression in chronic HBV patients among Asian populations (P = 1.55×10−7; OR = 0.50; 95% CI, 0.39–0.65). Trans-ethnic association analyses identified Asian-specific associations of HLA-DP alleles and haplotypes with HBV infection or disease progression. The present findings will serve as a base for future functional studies of HLA-DP molecules in order to understand the pathogenesis of HBV infection and the development of hepatocellular carcinoma.
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影响因子：
--
作者：
Sawai H;Nishida N;Mbarek H;Matsuda K;Mawatari Y;Yamaoka M;Hige S;Kang JH;Abe K;Mochida S;Watanabe M;Kurosaki M;Asahina Y;Izumi N;Honda M;Kaneko S;Tanaka E;Matsuura K;Itoh Y;Mita E;Korenaga M;Hino K;Murawaki Y;Hiasa Y;Ide T;Ito K;Sugiyama M;Ahn SH;Han KH;Park JY;Yuen MF;Nakamura Y;Tanaka Y;Mizokami M;Tokunaga K
通讯作者：
Tokunaga K
影响因子：
3.7
作者：
Nishida N;Sawai H;Matsuura K;Sugiyama M;Ahn SH;Park JY;Hige S;Kang JH;Suzuki K;Kurosaki M;Asahina Y;Mochida S;Watanabe M;Tanaka E;Honda M;Kaneko S;Orito E;Itoh Y;Mita E;Tamori A;Murawaki Y;Hiasa Y;Sakaida I;Korenaga M;Hino K;Ide T;Kawashima M;Mawatari Y;Sageshima M;Ogasawara Y;Koike A;Izumi N;Han KH;Tanaka Y;Tokunaga K;Mizokami M
通讯作者：
Mizokami M
影响因子：
3.7
作者：
Kim DW;Lee SA;Hwang ES;Kook YH;Kim BJ
通讯作者：
Kim BJ
人类白细胞抗原/DP-DQ 的遗传变异影响乙型肝炎病毒清除和肝细胞癌的发展
影响因子：
13.5
作者：
Hu, Lingmin;Zhai, Xiangjun;Hu, Zhibin
通讯作者：
Hu, Zhibin
影响因子：
2.7
作者：
CHANDANAYINGYONG, D;STEPHENS, HAF;RUNGRUANG, E
通讯作者：
RUNGRUANG, E