Accumulation of connective tissue growth factor+ cells during the early phase of rat traumatic brain injury.
Accumulation of connective tissue growth factor+ cells during the early phase of rat traumatic brain injury.
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DOI：
10.1186/1746-1596-9-141
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发表时间：
2014-07-10
影响因子：
2.6
通讯作者：
Zhang Z
中科院分区：
文献类型：
--
作者：
Liu Y;Liu Z;Li X;Luo B;Xiong J;Gan W;Jiang M;Zhang Z;Schluesener HJ;Zhang Z
胶质瘢痕形成是创伤性脑损伤（TBI）常见的组织病理学特征。星形胶质细胞增生和转化生长因子β（TGF-β）的表达是瘢痕形成和血脑屏障调节的关键组成部分。结缔组织生长因子（CTGF）被认为是介导TGF-β作用的细胞因子。在这里，我们研究了CTGF的表达在一个开放的头骨重量下降诱导的TBI，重点是早期阶段，最适合治疗。在我们研究的正常大鼠脑中，很少观察到CTGF+细胞。TBI后72 h观察到CTGF+非神经元细胞的显著实质积累，并且在研究时间内持续增加。我们还观察到聚集的CTGF+非神经元细胞主要分布在病灶周围区域，并显示活化的星形胶质细胞表型，具有典型的星状形态特征。我们的观察结果表明，TBI中细胞CTGF表达的时间依赖性和损伤相关的积累，表明CTGF在TBI中的病理作用。本文的虚拟幻灯片可以在这里找到：http://www.diagnosticpathology.diagnomx.eu/vs/3963462091241165
Glial scar formation is a common histopathological feature of traumatic brain injury (TBI). Astrogliosis and expression of transforming growth factor beta (TGF-β) are key components of scar formation and blood-brain barrier modulation. Connective tissue growth factor (CTGF) is considered a cytokine mediating the effects of TGF-β. Here, we studied the CTGF expression in an open-skull weight-drop-induced TBI, with a focus on the early phase, most amenable to therapy. In normal rat brains of our study, CTGF+ cells were rarely observed. Significant parenchymal accumulation of CTGF+ non-neuron cells was observed 72 h post-TBI and increased continuously during the investigating time. We also observed that the accumulated CTGF+ non-neuron cells were mainly distributed in the perilesional areas and showed activated astrocyte phenotypes with typical stellate morphologic characteristics. Our observations demonstrated the time-dependent and lesion-associated accumulation of cellular CTGF expression in TBI, suggesting a pathological role of CTGF in TBI. The virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/3963462091241165
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影响因子：
3.4
作者：
Hertel, M;Tretter, Y;Werner, S
通讯作者：
Werner, S
影响因子：
3.3
作者：
Zhang, Z.;Artelt, M.;Schluesener, H. J.
通讯作者：
Schluesener, H. J.
影响因子：
5
作者：
Schwab, JM;Postler, E;Schluesener, HJ
通讯作者：
Schluesener, HJ
DOI：
10.1016/s1357-2725(98)00046-6
发表时间：
1998-08-01
影响因子：
4
作者：
Dammeier, J;Brauchle, M;Werner, S
通讯作者：
Werner, S
影响因子：
1.7
作者：
Liu, Yuqi;Zhang, Zhiyuan;Zhang, Zhiren
通讯作者：
Zhang, Zhiren