The antiviral activities and mechanisms of marine polysaccharides: an overview.
The antiviral activities and mechanisms of marine polysaccharides: an overview.
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DOI：
10.3390/md10122795
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发表时间：
2012-12-12
期刊：
影响因子：
5.4
通讯作者：
Guan HS
中科院分区：
文献类型：
--
作者：
Wang W;Wang SX;Guan HS
近年来，海洋天然产物特别是海洋多糖的抗病毒活性研究越来越受到国内外的关注。海洋多糖及其低分子量寡糖衍生物具有多种抗病毒活性。本文就近年来海洋生物多糖的抗病毒活性及其作用机制的研究进展作一综述。特别是对海藻硫酸多糖的抗病毒作用进行了综述，包括卡拉胶、海藻酸盐和岩藻聚糖等，并对其结构特征和构效关系进行了分析。此外，对海洋多糖抗病毒作用的不同机制及其潜在的治疗应用的最新研究结果也将进行详细总结。
Recently, the studies on the antiviral activities of marine natural products, especially marine polysaccharides, are attracting more and more attention all over the world. Marine-derived polysaccharides and their lower molecular weight oligosaccharide derivatives have been shown to possess a variety of antiviral activities. This paper will review the recent progress in research on the antiviral activities and the mechanisms of these polysaccharides obtained from marine organisms. In particular, it will provide an update on the antiviral actions of the sulfated polysaccharides derived from marine algae including carrageenans, alginates, and fucans, relating to their structure features and the structure–activity relationships. In addition, the recent findings on the different mechanisms of antiviral actions of marine polysaccharides and their potential for therapeutic application will also be summarized in detail.
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影响因子：
5.7
作者：
Debbab A;Aly AH;Lin WH;Proksch P
通讯作者：
Proksch P
影响因子：
3.1
作者：
Artan, Murat;Karadeniz, Fatih;Kim, Se-Kwon
通讯作者：
Kim, Se-Kwon
影响因子：
2.9
作者：
Copeland, Ronald;Balasubramaniam, Arun;Liu, Jian
通讯作者：
Liu, Jian
影响因子：
4.8
作者：
Grassauer A;Weinmuellner R;Meier C;Pretsch A;Prieschl-Grassauer E;Unger H
通讯作者：
Unger H
影响因子：
8.8
作者：
De Clercq, E
通讯作者：
De Clercq, E