Myosin II Controls Junction Fluctuations to Guide Epithelial Tissue Ordering.
Myosin II Controls Junction Fluctuations to Guide Epithelial Tissue Ordering.
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DOI：
10.1016/j.devcel.2017.09.018
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发表时间：
2017-11-20
影响因子：
11.8
通讯作者：
Baum B
中科院分区：
文献类型：
--
作者：
Curran S;Strandkvist C;Bathmann J;de Gennes M;Kabla A;Salbreux G;Baum B
在稳态条件下，个体粘附连接（AJs）长度的动态变化为上皮细胞提供了在面对内在和外在力时保持组织完整性所需的流动性。虽然AJ重塑对发育形态发生的贡献已被深入研究，但在其他情况下对AJ动力学知之甚少。在这里，我们研究AJ动态上皮细胞经历了一个逐渐增加的包装顺序，没有伴随大规模的组织大小或形状的变化。我们发现，邻居交换事件是由随机波动的连接长度，部分由连接肌动球蛋白调节。在这种情况下，各向同性连接肌动球蛋白的发育增加降低了邻居交换的速率，有助于组织秩序。我们提出了一个模型，在该模型中，连接处之间的张力的局部变化决定了基于肌动球蛋白的力是否会抑制或驱动拓扑结构的转变，无论是细化或变形的组织。连接长度的波动导致相邻交换事件而无形态发生连接张力的变化决定了肌动球蛋白如何影响T1速率整体增加连接肌动球蛋白水平抑制相邻交换各向同性连接张力的发育增加细化细胞包装Curran et al.研究果蝇背中的粘附连接重塑，其中肌动球蛋白水平的差异驱动连接长度和相邻交换的波动，但不是形态发生。全球交界紧张的发展增加减少，而不是驱动器，邻居交换，以促进组织排序。
Under conditions of homeostasis, dynamic changes in the length of individual adherens junctions (AJs) provide epithelia with the fluidity required to maintain tissue integrity in the face of intrinsic and extrinsic forces. While the contribution of AJ remodeling to developmental morphogenesis has been intensively studied, less is known about AJ dynamics in other circumstances. Here, we study AJ dynamics in an epithelium that undergoes a gradual increase in packing order, without concomitant large-scale changes in tissue size or shape. We find that neighbor exchange events are driven by stochastic fluctuations in junction length, regulated in part by junctional actomyosin. In this context, the developmental increase of isotropic junctional actomyosin reduces the rate of neighbor exchange, contributing to tissue order. We propose a model in which the local variance in tension between junctions determines whether actomyosin-based forces will inhibit or drive the topological transitions that either refine or deform a tissue. Fluctuations in junction length cause neighbor exchange events without morphogenesis The variance in junction tension determines how actomyosin influences T1 rates Globally increasing junctional actomyosin levels inhibits neighbor exchange A developmental increase in isotropic junction tension refines cellular packing Curran et al. investigate adherens junction remodeling in the fly notum, where differences in actomyosin levels drive fluctuations in junction length and neighbor exchange, but not morphogenesis. A developmental increase in global junctional tension reduces, rather than drives, neighbor exchange to promote tissue ordering.
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