Genomic biomarkers for molecular imaging: predicting the future.
Genomic biomarkers for molecular imaging: predicting the future.
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DOI：
10.1053/j.semnuclmed.2009.03.006
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发表时间：
2009-07
影响因子：
4.9
通讯作者：
Thakur ML
中科院分区：
文献类型：
--
作者：
Thakur ML
在过去的几十年里，在疾病的解剖成像方面取得了巨大的进步，从而使其诊断具有最小的侵入性。尽管取得了这些进展，但仅在美国，像癌症这样的疾病就继续每分钟夺走一个人的生命。直接与疾病发生有关的补充方法可能有助于其早期诊断和随后的管理。在癌症中，已经确定了一系列分子异常，导致细胞信号传导途径和细胞增殖中重要的关键蛋白质表达的调节。这些特定的疾病指纹，生物标志物，在恶性细胞表面或细胞质内过度表达，并提供独特的靶点，有望改善癌症诊断和治疗。我们，除其他外，设计，合成，并评估了一些新的探针特异性的癌基因和癌基因产物的生物标志物的PET和SPECT分子成像的某些类型的癌症。本文简要介绍了这种方法，并给出了具体的例子，描述了分子成像检测隐匿性病变的能力，目前的前列腺造影方法检测不到。本文还概述了一些示例，预测了针对此类尚未使用的特定探针的其他可能应用。
Over the past few decades great strides have been made in anatomical imaging of disease that has lead to their diagnosis with minimal invasion. Despite these advances, disease like cancer continues to take one human life every minute in the USA alone. Complimentary approaches that pertain directly to the genesis of the disease might contribute to its early diagnosis and subsequent management. In cancer, an array of molecular abnormalities leading to the modulations in expression of key proteins important in the cellular signaling pathways and cell proliferation has been identified. These specific disease fingerprints, biomarkers, are over expressed on malignant cell surfaces or within the cytoplasm and provide unique targets and promise to improve cancer diagnosis and therapy. We, among others, have designed, synthesized, and evaluated some novel probes specific for those oncogenes and oncogene product biomarkers for PET and SPECT molecular imaging of certain types of cancers. This article briefly describes this approach and gives specific examples which depict the ability of molecular imaging to detect occult lesions not detectable by current scintigraphic approaches. The article also outlines a few examples predicting other possible applications of targeting such specific probes not yet utilized.
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癌组学对癌症生物标志物发现的贡献。
影响因子：
37.3
作者：
Cho, William C S
通讯作者：
Cho, William C S
影响因子：
3.1
作者：
Germano, PM;Le, SV;Pisegna, JR
通讯作者：
Pisegna, JR
影响因子：
6.2
作者：
GIOVANNUCCI, E
通讯作者：
GIOVANNUCCI, E
DOI：
10.1073/pnas.0710575105
发表时间：
2008-04-15
影响因子：
11.1
作者：
Keren, S.;Zavaleta, C.;Gambhir, S. S.
通讯作者：
Gambhir, S. S.
影响因子：
3.1
作者：
Rao, PS;Thakur, ML;Marcus, CS
通讯作者：
Marcus, CS