Soymorphin-5, a soy-derived μ-opioid peptide, decreases glucose and triglyceride levels through activating adiponectin and PPARα systems in diabetic KKAy mice.
Soymorphin-5, a soy-derived μ-opioid peptide, decreases glucose and triglyceride levels through activating adiponectin and PPARα systems in diabetic KKAy mice.
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Soymorphin-5 是一种源自大豆的 μ-阿片肽，通过激活糖尿病 KKAy 小鼠的脂联素和 PPARα 系统来降低葡萄糖和甘油三酯水平。
DOI：
10.1152/ajpendo.00161.2011
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发表时间：
2012
期刊：
影响因子：
--
通讯作者：
Kousaku Ohinata
中科院分区：
文献类型：
--
作者：
Yuko Yamada;A. Muraki;M. Oie;Norimasa Kanegawa;A. Oda;Yurina Sawashi;Kentaro Kaneko;M. Yoshikawa;T. Goto;N. Takahashi;T. Kawada;Kousaku Ohinata
Soymorphin-5 (YPFVV) 源自大豆 β-伴大豆球蛋白 β-亚基，是一种具有抗焦虑样活性的 μ-阿片激动剂肽。在这里，我们证明，长期口服 soymorphin-5 可以改善 2 型糖尿病模型动物 KKAy 小鼠的葡萄糖和脂质代谢。 Soymorphin-5 可抑制 KKAy 小鼠的高血糖，且不会增加血浆胰岛素水平。 Soymorphin-5 还降低了血浆和肝脏甘油三酯 (TG) 水平以及肝脏重量，表明 soymorphin-5 改善了脂质代谢。 Soymorphin-5 增加血浆脂联素浓度和肝脏 AdipoR2 mRNA 表达，AdipoR2 是脂联素受体的一种亚型，参与刺激过氧化物酶体增殖物激活受体 (PPAR)α 途径和脂肪酸 β-氧化。口服soymorphin-5后，肝脏中PPARα及其靶基因酰基辅酶A氧化酶、肉碱棕榈酰转移酶1A和解偶联蛋白2的mRNA表达也增加。此外，不含μ-阿片类药物和抗焦虑样活性的 des-Tyr-soymorphin-5 (PFVV) 不会降低 KKAy 小鼠的血糖水平。这些结果表明，μ-阿片肽 soymorphin-5 通过激活脂联素和 PPARα 系统以及随后增加 KKAy 小鼠的 β-氧化和能量消耗来改善葡萄糖和脂质代谢。
Soymorphin-5 (YPFVV) derived from soybean β-conglycinin β-subunit is a μ-opioid agonist peptide having anxiolytic-like activity. Here, we show that soymorphin-5 improves glucose and lipid metabolism after long-term oral administration to KKAy mice, a type 2 diabetes model animal. Soymorphin-5 inhibited hyperglycemia without an increase in plasma insulin levels in KKAy mice. Soymorphin-5 also decreased plasma and liver triglyceride (TG) levels and liver weight, suggesting that soymorphin-5 improved lipid metabolism. Soymorphin-5 increased plasma adiponectin concentration and liver mRNA expression of AdipoR2, a subtype of adiponectin receptor that is involved in stimulating the peroxisome proliferator-activated receptor (PPAR)α pathway and fatty acid β-oxidation. The expressions of the mRNA of PPARα and its target genes acyl-CoA oxidase, carnitine palmitoyltransferase 1 A, and uncoupling protein-2, in the liver were also increased after oral administration of soymorphin-5. Furthermore, des-Tyr-soymorphin-5 (PFVV) without μ-opioid and anxiolytic-like activities did not decrease blood glucose levels in KKAy mice. These results suggest that μ-opioid peptide soymorphin-5 improves glucose and lipid metabolism via activation of the adiponectin and PPARα system and subsequent increases of β-oxidation and energy expenditure in KKAy mice.
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影响因子：
3.5
作者：
Takahashi, N;Kawada, T;Fushiki, T
通讯作者：
Fushiki, T
循环胆囊收缩素增加导致过度表达胰多肽的小鼠厌食和焦虑行为
影响因子：
--
作者：
N. Ueno;A. Asakawa;Yoshiko Satoh;A. Inui
通讯作者：
A. Inui
影响因子：
3.5
作者：
Kousaku Ohinata;Kuniko Takagi;Kyoko Biyajima;Y. Fujiwara;S. Fukumoto;N. Eguchi;Y. Urade;A. Asakawa;M. Fujimiya;A. Inui;M. Yoshikawa
通讯作者：
Kousaku Ohinata;Kuniko Takagi;Kyoko Biyajima;Y. Fujiwara;S. Fukumoto;N. Eguchi;Y. Urade;A. Asakawa;M. Fujimiya;A. Inui;M. Yoshikawa
影响因子：
1.6
作者：
Moriyama, T;Kishimoto, K;Maebuchi, M
通讯作者：
Maebuchi, M
影响因子：
--
作者：
Kanazawa I;Yamaguchi T;Yano S;Yamauchi M;Yamamoto M;Sugimoto T
通讯作者：
Sugimoto T