Validity of Capsule Endoscopy in Monitoring Therapeutic Interventions in Patients with Crohn's Disease.
Validity of Capsule Endoscopy in Monitoring Therapeutic Interventions in Patients with Crohn's Disease.
复制标题
DOI：
10.3390/jcm7100311
复制
发表时间：
2018-09-29
影响因子：
3.9
通讯作者：
Nagoya University Crohn’s Disease Study Group
中科院分区：
文献类型：
--
作者：
Nakamura M;Yamamura T;Maeda K;Sawada T;Mizutani Y;Ishikawa T;Furukawa K;Ohno E;Kawashima H;Miyahara R;Koulaouzidis A;Hirooka Y;Nagoya University Crohn’s Disease Study Group
克罗恩病（CD）的黏膜愈合情况可通过胶囊内镜（CE）进行评估。然而，仅有少数研究利用CE来证明药物治疗的疗效。我们试图评估使用CE监测CD患者药物治疗效果的有效性。100名CD患者被纳入研究。所有患者在进行CE之前都进行了胃肠道（GI）通畅性检查。基线CE刘易斯评分（LS）≤135的患者被纳入非活动性CD组并结束研究。对于LS > 135的患者（活动性CD组），无论症状如何，均按照治疗医生的建议给予额外治疗。活动性CD组的患者在6个月后接受随访CE评估。在92名胃肠道通畅性得到确认并接受CE检查的患者中，40名（43.4%）的CE检查结果显示有活动性炎症。在29名LS > 135并接受额外药物治疗且接受随访CE的患者中，23名（79.3%）患者的LS有所改善。11名患者无症状但接受了额外药物治疗；其中8名（72.7%）的LS有所改善。这项研究表明，即使对于临床缓解但CE显示小肠有活动性炎症的CD患者，给予额外治疗也可减少黏膜损伤。
Mucosal healing in Crohn’s disease (CD) can be evaluated by capsule endoscopy (CE). However, only a few studies have utilized CE to demonstrate the therapeutic effect of medical treatment. We sought to evaluate the validity of using CE to monitor the effect of medical treatment in patients with CD. One hundred (n = 100) patients with CD were enrolled. All patients had a gastrointestinal (GI) tract patency check prior to CE. Patients with baseline CE Lewis score (LS) ≤ 135 were included in the non-active CD group and ended the study. In those with LS > 135 (active CD group), additional treatment was administered, regardless of symptoms, as per the treating clinician’s advice. Patients of the active CD group underwent follow-up CE assessment 6 months later. Out of 92 patients with confirmed GI patency who underwent CE, 40 (43.4%) had CE findings of active inflammation. Of 29 patients with LS > 135 who received additional medications and underwent follow-up CE, improvement of the LS was noted in 23 (79.3%) patients. Eleven patients were asymptomatic but received additional medications; 8 (72.7%) had improvement of the LS. This study demonstrated that additional treatment even for patients with CD in clinical remission and active small-bowel inflammation on CE can reduce mucosal damage.
登录
查看更多内容
影响因子：
8
作者：
Peyrin-Biroulet, Laurent;Ferrante, Marc;Sturm, Andreas
通讯作者：
Sturm, Andreas
影响因子：
3.1
作者：
Koulaouzidis, Anastasios;Douglas, Sarah;Plevris, John N.
通讯作者：
Plevris, John N.
影响因子：
7.6
作者：
Gralnev, I. M.;Defranchis, R.;Lewis, B. S.
通讯作者：
Lewis, B. S.
影响因子：
168.9
作者：
Colombel, Jean-Frederic;Panaccione, Remo;D'Haens, Geert
通讯作者：
D'Haens, Geert
影响因子：
7.7
作者：
Brotz, Corey;Nandi, Neilanjan;Kastenberg, David
通讯作者：
Kastenberg, David