Neutrophil interactions with the sexually transmitted parasite Trichomonas vaginalis: implications for immunity and pathogenesis.
Neutrophil interactions with the sexually transmitted parasite Trichomonas vaginalis: implications for immunity and pathogenesis.
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DOI：
10.1098/rsob.200192
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发表时间：
2020-09
期刊：
影响因子：
5.8
通讯作者：
Mercer F
中科院分区：
文献类型：
--
作者：
Bhakta SB;Moran JA;Mercer F
滴虫病是人类第三大常见的性传播感染，由原生动物寄生虫阴道毛滴虫（Tv）引起。致病结果在女性中更常见，通常包括轻度阴道炎或宫颈炎。然而，与滴虫病相关的更严重的影响包括不良生殖结果。与其他传染性病原体一样，预测Tv感染的发病机制是寄生虫和宿主因素共同作用的结果。在感染部位，中性粒细胞是存在的最丰富的免疫细胞，并且可能在寄生虫清除和炎症病理学中起关键作用。在这里，我们讨论的证据表明，嗜中性粒细胞回家的网站Tv感染，杀死寄生虫，在某些情况下，寄生虫可能逃避嗜中性粒细胞定向杀死。在体外，该寄生虫被嗜中性粒细胞使用一种新的抗菌机制杀死，这种机制称为胞刺作用，可能涉及先天免疫和适应性免疫。虽然逃避机制目前大多是推测，但患者中Tv感染的持续存在强烈支持它们的存在。此外，Tv的许多菌株含有微生物共生体人型支原体或毛滴虫病毒，这两者都被预测会影响嗜中性粒细胞对寄生虫的反应。新的研究工具，特别是动物模型，将有助于揭示在滴虫病期间参与嗜热菌-Tv相互作用的许多因素的真实结果。
Trichomoniasis is the third most common sexually transmitted infection in humans and is caused by the protozoan parasite, Trichomonas vaginalis (Tv). Pathogenic outcomes are more common in women and generally include mild vaginitis or cervicitis. However, more serious effects associated with trichomoniasis include adverse reproductive outcomes. Like other infectious agents, pathogenesis from Tv infection is predicted to be the result of both parasite and host factors. At the site of infection, neutrophils are the most abundant immune cells present and probably play key roles in both parasite clearance and inflammatory pathology. Here, we discuss the evidence that neutrophils home to the site of Tv infection, kill the parasite, and that in some circumstances, parasites possibly evade neutrophil-directed killing. In vitro, the parasite is killed by neutrophils using a novel antimicrobial mechanism called trogocytosis, which probably involves both innate and adaptive immunity. While mechanisms of evasion are mostly conjecture at present, the persistence of Tv infections in patients argues strongly for their existence. Additionally, many strains of Tv harbour microbial symbionts Mycoplasma hominis or Trichomonasvirus, which are both predicted to impact neutrophil responses against the parasite. Novel research tools, especially animal models, will help to reveal the true outcomes of many factors involved in neutrophil-Tv interactions during trichomoniasis.
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影响因子：
3.6
作者：
ARROYO, R;GONZALEZROBLES, A;ALDERETE, JF
通讯作者：
ALDERETE, JF
影响因子：
3.4
作者：
Fichorova, Raina N.
通讯作者：
Fichorova, Raina N.
DOI：
10.1074/jbc.m115.651497
发表时间：
2016-01-08
期刊：
The Journal of biological chemistry
影响因子：
--
作者：
Fichorova RN;Yamamoto HS;Fashemi T;Foley E;Ryan S;Beatty N;Dawood H;Hayes GR;St-Pierre G;Sato S;Singh BN
通讯作者：
Singh BN
影响因子：
3.1
作者：
Dessì, D;Delogu, G;Rappelli, P
通讯作者：
Rappelli, P
影响因子：
6.4
作者：
Clark, RA
通讯作者：
Clark, RA