Use-Dependent Plasticity in Human Primary Motor Hand Area: Synergistic Interplay Between Training and Immobilization.
Use-Dependent Plasticity in Human Primary Motor Hand Area: Synergistic Interplay Between Training and Immobilization.
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DOI：
10.1093/cercor/bhy226
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发表时间：
2019-01-01
期刊：
影响因子：
--
通讯作者：
Siebner HR
中科院分区：
文献类型：
--
作者：
Raffin E;Siebner HR
训练和制动是人类初级运动手区（M1HAND）使用依赖性可塑性的强大驱动力。在年轻的右撇子志愿者中，左侧第一背侧骨间肌和小指外展肌的皮质运动表示与神经导航经颅磁刺激（TMS）映射，以阐明手指特异性训练和固定如何在M1HAND内相互作用。第一组志愿者接受了一周的训练，用左手食指或小指在智能手机上跟踪移动目标。线性沟形状的TMS映射显示，与训练的手指获得的跟踪技能转移到同一只手的nontrained手指。经过训练和未经训练的手指肌肉的皮质表征与技能转移成比例地收敛。在第二组中，食指或小指被固定一周。固定单独衰减的corticomotor的代表性和预先存在的跟踪技能的固定手指。在第三组中，手指固定的不利影响被同时训练的nonimmobilized手指。相反，固定的nontrained手指加速学习在相邻的培训手指在前2天的培训。总之，这些结果为使用依赖性皮层可塑性提供了新的见解，揭示了M1HAND内的协同而非竞争性相互作用模式。
Training and immobilization are powerful drivers of use-dependent plasticity in human primary motor hand area (M1HAND). In young right-handed volunteers, corticomotor representations of the left first dorsal interosseus and abductor digiti minimi muscles were mapped with neuronavigated transcranial magnetic stimulation (TMS) to elucidate how finger-specific training and immobilization interact within M1HAND. A first group of volunteers trained to track a moving target on a smartphone with the left index or little finger for one week. Linear sulcus shape-informed TMS mapping revealed that the tracking skill acquired with the trained finger was transferred to the nontrained finger of the same hand. The cortical representations of the trained and nontrained finger muscle converged in proportion with skill transfer. In a second group, the index or little finger were immobilized for one week. Immobilization alone attenuated the corticomotor representation and pre-existing tracking skill of the immobilized finger. In a third group, the detrimental effects of finger immobilization were blocked by concurrent training of the nonimmobilized finger. Conversely, immobilization of the nontrained fingers accelerated learning in the adjacent trained finger during the first 2 days of training. Together, the results provide novel insight into use-dependent cortical plasticity, revealing synergistic rather than competitive interaction patterns within M1HAND.
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