Photonic Crystal Surfaces as a General Purpose Platform for Label-Free and Fluorescent Assays.
Photonic Crystal Surfaces as a General Purpose Platform for Label-Free and Fluorescent Assays.
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DOI：
10.1016/j.jala.2009.10.009
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发表时间：
2010-04-01
期刊：
影响因子：
--
通讯作者：
Cunningham BT
中科院分区：
文献类型：
--
作者：
Cunningham BT
光子晶体表面可以被设计为提供用于执行生物化学和基于细胞的测定的广泛功能。检测来自光子晶体表面的光学共振反射能够实现高灵敏度的无标记生物传感，而在共振波长处发生的增强的电磁场可以用于增强任何基于表面的荧光测定的检测灵敏度。从廉价的塑料材料在大的表面积上制造光子晶体，使它们能够被纳入标准格式，包括微孔板，微阵列和微流体通道。本文综述了光子晶体生物传感器的设计、相关的检测仪器和生物学应用。应用包括小分子高通量筛选，细胞膜整合素活化，基因表达分析，蛋白质生物标志物检测突出。本文还介绍了光子晶体表面用于增强表面增强拉曼光谱检测的最新研究成果，以及基于光子晶体的高分辨率激光生物传感器的发展。
Photonic crystal surfaces can be designed to provide a wide range of functions that are used to perform biochemical and cell-based assays. Detection of the optical resonant reflections from photonic crystal surfaces enables high sensitivity label-free biosensing, while the enhanced electromagnetic fields that occur at resonant wavelengths can be used to enhance the detection sensitivity of any surface-based fluorescence assay. Fabrication of photonic crystals from inexpensive plastic materials over large surface areas enables them to be incorporated into standard formats that include microplates, microarrays, and microfluidic channels. This report reviews the design of photonic crystal biosensors, their associated detection instrumentation, and biological applications. Applications including small molecule high throughput screening, cell membrane integrin activation, gene expression analysis, and protein biomarker detection are highlighted. Recent results in which photonic crystal surfaces are used for enhancing the detection of Surface-Enhanced Raman Spectroscopy, and the development of high resolution photonic crystal-based laser biosensors are also described.
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影响因子：
3.8
作者：
Ganesh, Nikhil;Block, Ian D.;Cunningham, Brian T.
通讯作者：
Cunningham, Brian T.
影响因子：
3.2
作者：
Ganesh, Nikhil;Mathias, Patrick C.;Cunningham, Brian T.
通讯作者：
Cunningham, Brian T.
影响因子：
2.5
作者：
Haynes, CL;Yonzon, CR;Van Duyne, RP
通讯作者：
Van Duyne, RP
DOI：
10.1109/jstqe.2005.862945
发表时间：
2006-01-01
影响因子：
4.9
作者：
Chao, CY;Fung, W;Guo, LJ
通讯作者：
Guo, LJ
影响因子：
4.3
作者：
Block, Ian D.;Ganesh, Nikhil;Cunningham, Brian T.
通讯作者：
Cunningham, Brian T.