Characteristics and comparative clinical outcomes of prisoner versus non-prisoner populations hospitalized with COVID-19.
Characteristics and comparative clinical outcomes of prisoner versus non-prisoner populations hospitalized with COVID-19.
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DOI：
10.1038/s41598-021-85916-w
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发表时间：
2021-03-22
影响因子：
4.6
通讯作者：
Kak V
中科院分区：
文献类型：
--
作者：
Altibi AM;Pallavi B;Liaqat H;Slota AA;Sheth R;Al Jebbawi L;George ME;LeDuc A;Abdallah E;Russell LR;Jain S;Shirvanian N;Masri A;Kak V
美国的监狱已经成为在被监禁者中传播COVID-19的温床。囚犯中的COVID-19病例呈上升趋势，迄今已确诊超过143，000例。然而，关于因COVID-19住院的囚犯的临床结果和死亡率的数据很少。对2020年3月10日至5月10日期间在密歇根州两家亨利福特卫生系统医院住院的所有新冠肺炎患者进行的观察性研究。比较住院囚犯和非囚犯患者的临床结局。主要结局为插管率、住院死亡率和30天死亡率。多变量logistic回归和Cox回归模型用于研究主要结局。在706名住院的COVID-19患者中（平均年龄66.7 ± 16.1岁，57%为男性，44%为黑人），108名囚犯和598名非囚犯。与非囚犯相比，囚犯更容易出现发烧、呼吸急促、低氧血症和炎症标志物明显升高。囚犯更常入住重症监护室（ICU）（26.9%对18.7%），需要血管加压药（24.1%对9.9%）和插管（25.0%对15.2%）。囚犯有较高的未经调整的住院死亡率（29.6%对20.1%）和30天死亡率（34.3%对24.6%）。在调整后的模型中，囚犯身份与较高的住院死亡率（比值比，2.32; 95%置信区间（CI），1.33至4.05）和30天死亡率（风险比，2.00; 95% CI，1.33至3.00）相关。在这个住院的COVID-19患者队列中，囚犯身份与更严重的临床表现、更高的ICU入院率、血管加压药需求、插管、住院死亡率和30天死亡率相关。
Prisons in the United States have become a hotbed for spreading COVID-19 among incarcerated individuals. COVID-19 cases among prisoners are on the rise, with more than 143,000 confirmed cases to date. However, there is paucity of data addressing clinical outcomes and mortality in prisoners hospitalized with COVID-19. An observational study of all patients hospitalized with COVID-19 between March 10 and May 10, 2020 at two Henry Ford Health System hospitals in Michigan. Clinical outcomes were compared amongst hospitalized prisoners and non-prisoner patients. The primary outcomes were intubation rates, in-hospital mortality, and 30-day mortality. Multivariable logistic regression and Cox-regression models were used to investigate primary outcomes. Of the 706 hospitalized COVID-19 patients (mean age 66.7 ± 16.1 years, 57% males, and 44% black), 108 were prisoners and 598 were non-prisoners. Compared to non-prisoners, prisoners were more likely to present with fever, tachypnea, hypoxemia, and markedly elevated inflammatory markers. Prisoners were more commonly admitted to the intensive care unit (ICU) (26.9% vs. 18.7%), required vasopressors (24.1% vs. 9.9%), and intubated (25.0% vs. 15.2%). Prisoners had higher unadjusted inpatient mortality (29.6% vs. 20.1%) and 30-day mortality (34.3% vs. 24.6%). In the adjusted models, prisoner status was associated with higher in-hospital death (odds ratio, 2.32; 95% confidence interval (CI), 1.33 to 4.05) and 30-day mortality (hazard ratio, 2.00; 95% CI, 1.33 to 3.00). In this cohort of hospitalized COVID-19 patients, prisoner status was associated with more severe clinical presentation, higher rates of ICU admissions, vasopressors requirement, intubation, in-hospital mortality, and 30-day mortality.
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影响因子：
56.3
作者：
Tabata, Sakiko;Imai, Kazuo;Tamura, Kaku
通讯作者：
Tamura, Kaku
DOI：
10.4049/jimmunol.1601896
发表时间：
2017-05-15
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Channappanavar R;Fett C;Mack M;Ten Eyck PP;Meyerholz DK;Perlman S
通讯作者：
Perlman S
DOI：
10.1016/s1473-3099(10)70049-9
发表时间：
2010-05
期刊：
The Lancet. Infectious diseases
影响因子：
--
作者：
Klein SL;Jedlicka A;Pekosz A
通讯作者：
Pekosz A
影响因子：
3.3
作者：
Tomes, Nancy
通讯作者：
Tomes, Nancy
DOI：
10.1001/jama.2020.6775
发表时间：
2020-01-01
期刊：
JAMA, Journal of the American Medical Association
影响因子：
--
作者：
Richardson, Safiya;Hirsch, Jamie S.;,
通讯作者：
,