TCRαβ+ CD4-/CD8- "double negative" T cells in health and disease-implications for the kidney.
TCRαβ+ CD4-/CD8- "double negative" T cells in health and disease-implications for the kidney.
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DOI：
10.1016/j.kint.2022.02.035
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发表时间：
2022-07
影响因子：
19.6
通讯作者：
中科院分区：
文献类型：
--
作者：
双阴性（DN） T细胞是研究最少的T淋巴细胞亚群之一，表达T细胞受体（TCRαβ），但缺乏CD4和CD8共受体。在肾脏、肺、心脏、胃肠道、肝脏、生殖道和中枢神经系统等多个器官中都发现了DN T细胞。在包括实验性AKI在内的不同疾病模型中，DN T细胞抑制炎症反应，有重要证据支持其在SLE发病机制中发挥重要作用。然而，对这些细胞在其他肾脏疾病中的作用知之甚少。因此，更好地了解DN T细胞的不同功能及其信号通路作为有希望的治疗靶点是很重要的，特别是随着T细胞定向治疗在人类中的应用越来越多。在这篇综述中，我们旨在总结不同疾病模型下正常和病变器官中DN T细胞的研究，并以肾脏为重点。
Double negative (DN) T cells, one of the least studied T lymphocyte subgroups, express T cell receptor (TCRαβ) but lack CD4 and CD8 co-receptors. DN T cells are found in multiple organs including kidney, lung, heart, gastrointestinal tract, liver, genital tract and central nervous system. DN T cells suppress inflammatory responses in different disease models including experimental AKI and significant evidence supports an important role in the pathogenesis of SLE. However, little is known about these cells in other kidney diseases. Therefore, it is important to better understand different functions of DN T cells and their signaling pathways as promising therapeutic targets, particularly with the increasing application of T cell directed therapy in humans. In this review, we aim to summarize studies conducted on DN T cells in normal and diseased organs in the setting of different disease models with a focus on kidney.
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