Principles of microtubule polarity in linear cells.
Principles of microtubule polarity in linear cells.
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DOI：
10.1016/j.ydbio.2022.01.004
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发表时间：
2022-03
影响因子：
2.7
通讯作者：
Rolls, Melissa M.
中科院分区：
文献类型：
--
作者：
Rolls, Melissa M.
微管细胞骨架对于维持长和长寿的神经元至关重要。微管的重叠阵列从细胞体中的主要合成部位延伸到轴突和树突的远处。新的物质通过马达蛋白从细胞体沿着这些神经通路被运输出来，而构建单元和关于细胞其他部分状态的信息则通过反向运动的马达返回。由于马达蛋白只能沿着沿着微管向一个方向移动，因此正确的马达和正确定向的微管的组合对于使货物向正确的方向移动至关重要。在这篇综述中，我们专注于微管极性是如何建立和维持在神经元。乍一看，弄清楚微管在神经元中是如何组织的似乎很简单。毕竟，微管本质上是一根长得慢的负端和长得快的正端的棍子，在轴突和树突的狭窄管道中排列棍子应该是简单的。因此，令人惊讶的是，有多少机制有助于确保它们以正确的极性排列。这些机制中的一些操作以产生轴突的正端出极性，而另一些控制混合或负端出树突。
The microtubule cytoskeleton is critical for maintenance of long and long-lived neurons. The overlapping array of microtubules extends from the major site of synthesis in the cell body to the far reaches of axons and dendrites. New materials are transported from the cell body along these neuronal roads by motor proteins, and building blocks and information about the state of affairs in other parts of the cell are returned by motors moving in the opposite direction. As motor proteins walk only in one direction along microtubules, the combination of correct motor and correctly oriented microtubules is essential for moving cargoes in the right direction. In this review, we focus on how microtubule polarity is established and maintained in neurons. At first thought, it seems that figuring out how microtubules are organized in neurons should be simple. After all, microtubules are essentially sticks with a slow-growing minus end and faster-growing plus end, and arranging sticks within the constrained narrow tubes of axons and dendrites should be straightforward. It is therefore quite surprising how many mechanisms contribute to making sure they are arranged in the correct polarity. Some of these mechanisms operate to generate plus-end-out polarity of axons, and others control mixed or minus-end-out dendrites.
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影响因子：
2.5
作者：
Guha S;Patil A;Muralidharan H;Baas PW
通讯作者：
Baas PW
影响因子：
9.2
作者：
Kapitein, Lukas C.;Schlager, Max A.;Hoogenraad, Casper C.
通讯作者：
Hoogenraad, Casper C.
DOI：
10.1083/jcb.109.6.3085
发表时间：
1989-12
期刊：
The Journal of cell biology
影响因子：
--
作者：
Baas PW;Black MM;Banker GA
通讯作者：
Banker GA
影响因子：
3
作者：
Baas PW;Lin S
通讯作者：
Lin S
影响因子：
4
作者：
Feng, Chengye;Cleary, Joseph M.;Rolls, Melissa M.
通讯作者：
Rolls, Melissa M.