The Arabidopsis ORGAN SIZE RELATED 2 is involved in regulation of cell expansion during organ growth.
The Arabidopsis ORGAN SIZE RELATED 2 is involved in regulation of cell expansion during organ growth.
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拟南芥器官大小相关 2 参与器官生长过程中细胞扩张的调节。
DOI：
10.1186/s12870-014-0349-5
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发表时间：
2014-12-10
影响因子：
5.3
通讯作者：
Hu Y
中科院分区：
文献类型：
--
作者：
Qin Z;Zhang X;Zhang X;Feng G;Hu Y
在植物中，空气器官生长到其特征大小依赖于细胞增殖和扩张的协调。这两种不同的过程在器官发育过程中先后发生，并有一段时间重叠。然而，在器官生长过程中，细胞增殖和扩张的协同和协调调节的机制仍然知之甚少。本研究鉴定了一个新的拟南芥器官大小相关（OSR）基因OSR2，该基因参与器官生长过程中细胞扩增过程的调控。OSR2主要在通过细胞扩增生长的组织或器官中表达，OSR2的异位表达主要通过增强细胞扩增导致器官增大。我们进一步发现OSR2与ARGOS-LIKE （ARL）有冗余作用，ARL是另一个OSR基因，在器官生长过程中调节细胞扩张。此外，对三重和四重osr突变体的形态学和细胞学分析证实，四种osr成员以差异但合作的方式参与细胞增殖和细胞扩增的调节，从而调节最终的器官大小。我们的研究结果表明，OSR2在器官生长过程中调控细胞扩增，这进一步暗示OSR成员参与细胞增殖和扩增的调控，从而调控最终的器官大小。这些发现，连同我们之前的研究，强烈表明osr介导的器官生长可能是植物器官发生过程中细胞增殖和扩增协同调节的一种进化机制。本文的在线版本（doi:10.1186/s12870-014-0349-5）包含补充材料，可供授权用户使用。
In plants, the growth of an aerial organ to its characteristic size relies on the coordination of cell proliferation and expansion. These two different processes occur successively during organ development, with a period of overlap. However, the mechanism underlying the cooperative and coordinative regulation of cell proliferation and expansion during organ growth remains poorly understood. This study characterized a new Arabidopsis ORGAN SIZE RELATED (OSR) gene, OSR2, which participates in the regulation of cell expansion process during organ growth. OSR2 was expressed primarily in tissues or organs undergoing growth by cell expansion, and the ectopic expression of OSR2 resulted in enlarged organs, primarily through enhancement of cell expansion. We further show that OSR2 functions redundantly with ARGOS-LIKE (ARL), another OSR gene that regulates cell expansion in organ growth. Moreover, morphological and cytological analysis of triple and quadruple osr mutants verified that the four OSR members differentially but cooperatively participate in the regulation of cell proliferation and cell expansion and thus the final organ size. Our results reveal that OSR2 is functional in the regulation of cell expansion during organ growth, which further implicates the involvement of OSR members in the regulation of both cell proliferation and expansion and thus the final organ size. These findings, together with our previous studies, strongly suggest that OSR-mediated organ growth may represent an evolutionary mechanism for the cooperative regulation of cell proliferation and expansion during plant organogenesis. The online version of this article (doi:10.1186/s12870-014-0349-5) contains supplementary material, which is available to authorized users.
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影响因子：
6.9
作者：
Guo M;Rupe MA;Wei J;Winkler C;Goncalves-Butruille M;Weers BP;Cerwick SF;Dieter JA;Duncan KE;Howard RJ;Hou Z;Löffler CM;Cooper M;Simmons CR
通讯作者：
Simmons CR
影响因子：
7.2
作者：
Clough, SJ;Bent, AF
通讯作者：
Bent, AF
影响因子：
2.7
作者：
Donnelly, PM;Bonetta, D;Dengler, NG
通讯作者：
Dengler, NG
影响因子：
4.9
作者：
Kazama, Toshiya;Ichihashi, Yasunori;Tsukaya, Hirokazu
通讯作者：
Tsukaya, Hirokazu
影响因子：
5.6
作者：
Kalve S;De Vos D;Beemster GT
通讯作者：
Beemster GT