The different maturation of the corticospinal tract and corticoreticular pathway in normal brain development: diffusion tensor imaging study.
The different maturation of the corticospinal tract and corticoreticular pathway in normal brain development: diffusion tensor imaging study.
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DOI：
10.3389/fnhum.2014.00573
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发表时间：
2014
影响因子：
2.9
通讯作者：
Son SM
中科院分区：
文献类型：
--
作者：
Yeo SS;Jang SH;Son SM
背景和目的：皮质脊髓束（CST）和皮质网状通路（CRP）是运动发育的重要神经束。然而，关于CST和CRP成熟的差异知之甚少。在这项研究中，使用扩散张量成像（DTI），我们调查了成熟的CST和CRP在典型发育的儿童和正常健康成人。方法：我们招募了75名正常健康受试者。采用1.5-T磁共振成像仪进行DTI检查，应用DTI-Studio软件对CST和CRP进行重建。测量CST和CRP的各向异性分数（FA）和纤维体积（FV）。结果：在本研究中，CST和CRP成熟的阈值点在正常脑发育中是不同的。CST的FA值变化显示急剧增加，直到7岁，然后逐渐增加，直到成年，然而，CRP仅显示急剧增加，直到2岁，然后非常逐渐增加或平台，直到成年。在FV方面，CST在12岁之前急剧增加，然后逐渐增加直到成年，而CRP在整个年龄范围（0-25岁）内显示FV逐渐增加。结论：CST和CRP成熟过程的差异可能与精细运动和粗大运动发育的不同时期有关。这些放射学信息可以为理解运动功能的发展提供科学依据。
Background and Purpose: The corticospinal tract (CST) and corticoreticular pathway (CRP) are known to be important neural tracts for motor development. However, little is known about the difference in maturation of the CST and CRP. In this study, using diffusion tensor imaging (DTI), we investigated maturation of the CST and CRP in typically developed children and normal healthy adults. Methods: We recruited 75 normal healthy subjects for this study. DTI was performed using 1.5-T, and the CST and CRP were reconstructed using DTI-Studio software. Values of fractional anisotropy (FA) and fiber volume (FV) of the CST and CRP were measured. Results: In the current study, the threshold points for CST and CRP maturation were different in normal brain development. Change in FA value of the CST showed a steep increase until 7 years of age and then a gradual increase until adulthood, however, the CRP showed a steep increase only until 2 years of age and then a very gradual increase or plateau until adulthood. In terms of FV, the CST showed a steep increase until 12 years and then a gradual increase until adulthood, in contrast, the CRP showed gradual increase of FV across whole age range (0–25 years). Conclusion: The difference in maturation process between CST and CRP appears to be related to different periods of fine and gross motor development. This radiologic information can provide a scientific basis for understanding development in motor function.
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DOI：
10.1098/rstb.2005.1639
发表时间：
2005-05-29
影响因子：
6.3
作者：
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通讯作者：
Alexander, DC
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影响因子：
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通讯作者：
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