Insufficient sleep undermines dietary efforts to reduce adiposity.
Insufficient sleep undermines dietary efforts to reduce adiposity.
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DOI：
10.7326/0003-4819-153-7-201010050-00006
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发表时间：
2010-10-05
影响因子：
39.2
通讯作者：
Penev PD
中科院分区：
文献类型：
--
作者：
Nedeltcheva AV;Kilkus JM;Imperial J;Schoeller DA;Penev PD
睡眠不足会改变能量的摄入和消耗。确定睡眠限制是否减弱低热量饮食对过度肥胖的影响。随机两阶段两条件交叉研究。大学临床研究中心和睡眠实验室。10例超重非吸烟成人（3例女性/7例男性）;平均（SD）年龄41（5）岁;体重指数27.4（2.0）kg/m2。14天的中度热量限制，夜间睡眠时间为8.5或5.5小时。主要：脂肪和无脂肪体重的损失。次要：底物利用率、能量消耗、饥饿和24小时代谢激素浓度的变化。睡眠缩短使体重减轻的脂肪比例降低了55%（1.4与0.6 kg，8.5与5.5小时睡眠机会，P=0.043），使无脂肪体重减轻增加了60%（1.5与2.4 kg，P=0.002）。这伴随着对热量限制的神经内分泌适应增强的标志物，饥饿感增加，以及相对底物利用向较少脂肪氧化的转变。研究的性质限制了其持续时间和样本量。人类的睡眠量有助于在能量摄入减少的情况下维持无脂肪的体重。缺乏足够的睡眠可能会损害典型的饮食干预对减肥和相关代谢风险降低的功效。
Sleep loss can modify energy intake and expenditure. To determine whether sleep restriction attenuates the effect of reduced-calorie diet on excess adiposity. Randomized two-period two-condition crossover study. University clinical research center and sleep laboratory. 10 overweight nonsmoking adults (3F/7M); mean (SD) age 41 (5) y; body mass index 27.4 (2.0) kg/m2. 14 days of moderate caloric restriction with 8.5 or 5.5-hour nighttime sleep opportunity. Primary: loss of fat and fat-free body mass. Secondary: changes in substrate utilization, energy expenditure, hunger, and 24-h metabolic hormone concentrations. Sleep curtailment decreased the fraction of weight lost as fat by 55% (1.4 vs. 0.6 kg with 8.5 vs. 5.5-h sleep opportunity, P=0.043) and increased the loss of fat-free body mass by 60% (1.5 vs. 2.4 kg, P=0.002). This was accompanied by markers of enhanced neuroendocrine adaptation to caloric restriction, increased hunger, and a shift in relative substrate utilization towards oxidation of less fat. The nature of the study limited its duration and sample size. The amount of human sleep contributes to the maintenance of fat-free body mass at times of decreased energy intake. Lack of sufficient sleep may compromise the efficacy of typical dietary interventions for weight loss and related metabolic risk reduction.
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影响因子：
4.8
作者：
HILL, AJ;BLUNDELL, JE
通讯作者：
BLUNDELL, JE
影响因子：
4.9
作者：
Rodriguez, A.;Gomez-Ambrosi, J.;Fruehbeck, G.
通讯作者：
Fruehbeck, G.
影响因子：
5.8
作者：
Shea, SA;Hilton, MF;Mantzoros, CS
通讯作者：
Mantzoros, CS
响应热量限制的代谢和行为补偿：维持体重减轻的影响。
影响因子：
3.7
作者：
Redman LM;Heilbronn LK;Martin CK;de Jonge L;Williamson DA;Delany JP;Ravussin E;Pennington CALERIE Team
通讯作者：
Pennington CALERIE Team
影响因子：
15.9
作者：
BOYLE, PJ;SCOTT, JC;HOFFMAN, C
通讯作者：
HOFFMAN, C