Resting-state spontaneous fluctuations in brain activity: a new paradigm for presurgical planning using fMRI.

Resting-state spontaneous fluctuations in brain activity: a new paradigm for presurgical planning using fMRI.
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大脑活动的静息态自发波动:使用功能磁共振成像进行术前计划的新范例。

DOI:
10.1016/j.acra.2009.02.001
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发表时间:
2009-05
期刊:
影响因子:
4.8
通讯作者:
Leuthardt, Eric C.
Leuthardt, Eric C.
中科院分区:
医学3区
文献类型:
--
作者:
Shimony, Joshua S.;Zhang, Dongyang;Johnston, James M.;Fox, Michael D.;Roy, Abhik;Leuthardt, Eric C.

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任务诱发功能磁共振成像已成功地应用于脑功能的研究,并在临床上用于脑外科手术前脑功能区的定位。这种方法需要患者合作,对认知功能障碍或身体损伤的患者不起作用。另一种可以克服其中一些缺点的方法是使用静息状态的功能磁共振成像来测量大脑的内在功能。这种方法不需要任何任务执行,并且测量fMRI信号随时间的自发低频(<0.1赫兹)波动。静息状态的fMRI数据可以为许多患者提供有价值的术前信息,这些患者无法从传统的基于任务的fMRI中受益。在本综述中,我们的目标是提供初步信息,包括该技术的优势和仍然存在的挑战,以改善术前计划和以患者为中心的个体化护理。
Task evoked functional MRI (fMRI) has been used successfully in the study of brain function and clinically for pre-surgical localization of eloquent brain regions prior to the performance of brain surgery. This method requires patient cooperation and is not useful in patients with cognitive dysfunction or physical impairment. An alternative method that can overcome some of these disadvantages measures the intrinsic function of the brain using resting state fMRI. This method does not require any task performance and measures the spontaneous low frequency (<0.1 Hz) fluctuations of the fMRI signal over time. Resting state fMRI data can provide valuable pre-surgical information in many patients who cannot benefit from traditional task based fMRI. Our objective in the current review is to provide preliminary information, including advantages and remaining challenges, on the clinical utility of this technique for improving pre-surgical planning and individualized patient centered care.
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