An in vitro spectroscopic analysis to determine whether para-chloroaniline is produced from mixing sodium hypochlorite and chlorhexidine.
An in vitro spectroscopic analysis to determine whether para-chloroaniline is produced from mixing sodium hypochlorite and chlorhexidine.
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DOI：
10.1016/j.joen.2009.10.028
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发表时间：
2010-02
影响因子：
4.2
通讯作者：
Sem DS
中科院分区：
文献类型：
--
作者：
Thomas JE;Sem DS
本体外研究的目的是确定次氯酸钠（NaOCl）和氯己定（CHX）混合后是否会形成对氯苯胺（PCA）。最初市售的醋酸氯己定（CHXA）和PCA样品采用1H NMR光谱法进行了分析。将两种溶液NaOCl和CHXa加热至37°C，并且当混合时，它们产生棕色沉淀。将该沉淀物分成两半，并将纯PCA加入其中一个样品中进行比较，然后用1H NMR光谱法分析它们。CHXa和PCA的1H NMR谱中的峰被指定为分子的特定质子，并且PCA谱中的芳香族峰的位置定义了PCA双峰区域。虽然单独沉淀物的光谱导致复杂的峰组合，但在放大后，在PCA双峰区域中没有强度足以定量的峰。在添加PCA的沉淀物的光谱中，在PCA双峰区域中确实出现两个峰。将该光谱与单独沉淀物的光谱进行比较，在添加PCA之前，PCA双峰区域中的峰不可见。根据这项体外研究，NaOCl和CHXa的反应混合物不会产生任何可测量量的五氯苯甲醚，需要进一步研究以确定棕色沉淀物的化学成分。
The purpose of this in vitro study was to determine whether para-chloroaniline (PCA) is formed through the reaction of mixing sodium hypochlorite (NaOCl) and chlorhexidine (CHX). Initially commercially available samples of chlorhexidine acetate (CHXa) and PCA were analyzed with 1H NMR spectroscopy. Two solutions, NaOCl and CHXa, were warmed to 37°C and when mixed they produced a brown precipitate. This precipitate was separated in half and pure PCA was added to one of the samples for comparison before they were each analyzed with 1H NMR spectroscopy. The peaks in the 1H NMR spectra of CHXa and PCA were assigned to specific protons of the molecules, and the location of the aromatic peaks in the PCA spectrum defined the PCA doublet region. While the spectrum of the precipitate alone resulted in a complex combination of peaks, upon magnification there were no peaks in the PCA doublet region which were intense enough to be quantified. In the spectrum of the precipitate, to which PCA was added, two peaks do appear in the PCA doublet region. Comparing this spectrum to that of precipitate alone, the peaks in the PCA doublet region are not visible prior to the addition of PCA. Based on this in vitro study, the reaction mixture of NaOCl and CHXa does not produce PCA at any measurable quantity and further investigation is needed to determine the chemical composition of the brown precipitate.
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影响因子：
5
作者：
Gomes, BPFA;Ferraz, CCR;Souza, FJ
通讯作者：
Souza, FJ
影响因子：
4.2
作者：
Bui, Tung B.;Baumgartner, J. Craig;Mitchell, John C.
通讯作者：
Mitchell, John C.
影响因子：
4.2
作者：
Kishen, Anil;Sum, Chee-Peng;Lim, Chwee-Teck
通讯作者：
Lim, Chwee-Teck
DOI：
10.1016/s1079-2104(03)00360-3
发表时间：
2004-01-01
期刊：
ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY AND ENDODONTOLOGY
影响因子：
--
作者：
Vianna, ME;Gomes, BPFA;de Souza, FJ
通讯作者：
de Souza, FJ
影响因子：
4.2
作者：
White, RR;Hays, GL;Janer, LR
通讯作者：
Janer, LR