Pupillometry as a reliable metric of auditory detection and discrimination across diverse stimulus paradigms in animal models.
Pupillometry as a reliable metric of auditory detection and discrimination across diverse stimulus paradigms in animal models.
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瞳孔测量作为动物模型中不同刺激范式的听觉检测和辨别的可靠度量。
DOI：
10.1038/s41598-021-82340-y
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发表时间：
2021-02-04
影响因子：
4.6
通讯作者：
Sadagopan S
中科院分区：
文献类型：
--
作者：
Montes-Lourido P;Kar M;Kumbam I;Sadagopan S
检测和区分阈值的估计通常用于探索人类受试者和动物模型之间广泛的感知相似性。瞳孔测量法作为一种非侵入性、易于部署的比较人类和动物阈值的方法显示出巨大的前景。使用瞳孔测量法，先前的动物模型研究已经获得了简单刺激（如纯音）的阈值估计，但尚未探索复杂刺激是否可以引起类似的瞳孔反应，其他刺激偶然事件可能影响刺激引起的瞳孔反应，以及瞳孔反应是否可以通过经验或短期训练来调节。在这项研究中，我们使用听觉怪异范式来估计豚鼠在大范围刺激下的检测和辨别阈值。我们证明，瞳孔测量在一系列简单（音调）和复杂（同视发声）刺激中产生可靠的检测和区分阈值；瞳孔反应可以通过不同的刺激偶然性（低水平的声学变化，或更高水平的分类变化）被强烈地唤起；学生的反应是通过短期训练来调节的。这些结果为在大型实验队列中使用瞳孔测量法作为估计阈值的可靠方法奠定了基础，并揭示了使用瞳孔测量法探索人类和动物模型之间广泛相似性的全部潜力。
Estimates of detection and discrimination thresholds are often used to explore broad perceptual similarities between human subjects and animal models. Pupillometry shows great promise as a non-invasive, easily-deployable method of comparing human and animal thresholds. Using pupillometry, previous studies in animal models have obtained threshold estimates to simple stimuli such as pure tones, but have not explored whether similar pupil responses can be evoked by complex stimuli, what other stimulus contingencies might affect stimulus-evoked pupil responses, and if pupil responses can be modulated by experience or short-term training. In this study, we used an auditory oddball paradigm to estimate detection and discrimination thresholds across a wide range of stimuli in guinea pigs. We demonstrate that pupillometry yields reliable detection and discrimination thresholds across a range of simple (tones) and complex (conspecific vocalizations) stimuli; that pupil responses can be robustly evoked using different stimulus contingencies (low-level acoustic changes, or higher level categorical changes); and that pupil responses are modulated by short-term training. These results lay the foundation for using pupillometry as a reliable method of estimating thresholds in large experimental cohorts, and unveil the full potential of using pupillometry to explore broad similarities between humans and animal models.
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影响因子：
16.2
作者：
Reimer, Jacob;Froudarakis, Emmanouil;Cadwell, Cathryn R.;Yatsenko, Dimitri;Denfield, George H.;Tolias, Andreas S.
通讯作者：
Tolias, Andreas S.
DOI：
10.1007/s10162-019-00739-x
发表时间：
2019-12-02
影响因子：
2.4
作者：
Bala, Avinash D. S.;Whitchurch, Elizabeth A.;Takahashi, Terry T.
通讯作者：
Takahashi, Terry T.
影响因子：
2.4
作者：
HEFFNER, R;HEFFNER, H;MASTERTON, B
通讯作者：
MASTERTON, B
影响因子：
16.2
作者：
McGinley MJ;David SV;McCormick DA
通讯作者：
McCormick DA
影响因子：
3
作者：
Gay JD;Voytenko SV;Galazyuk AV;Rosen MJ
通讯作者：
Rosen MJ