Controversies on the origin of proliferating epithelial cells after kidney injury.
Controversies on the origin of proliferating epithelial cells after kidney injury.
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DOI：
10.1007/s00467-013-2669-3
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发表时间：
2014-04
影响因子：
3
通讯作者：
Humphreys, Benjamin D.
中科院分区：
文献类型：
--
作者：
Kusaba, Tetsuro;Humphreys, Benjamin D.
肾脏具有在急性损伤后修复的能力，即使是导致完全器官衰竭的损伤。这种再生反应的特征在于上皮细胞的强烈增殖，主要是位于近端小管中的上皮细胞。由于确定这些修复细胞的起源对干细胞和再生方法治疗肾损伤具有重要影响，因此该领域一直是激烈研究和辩论的主题。虽然在缩小这些细胞的可能来源于小管内来源方面取得了进展，但在预先存在的小管内干细胞或祖细胞的可能性与完全分化的上皮细胞在损伤后重新进入细胞周期并通过自我复制产生新的近端小管细胞的可能性之间尚未达成共识。这篇综述将总结这一积极的争议双方的证据，并提供支持的概念，没有预先存在的近端小管干细胞群的存在，而是所有分化的近端小管上皮细胞有能力在修复过程中增殖的去分化和自我复制的机制。
The kidney possesses the capacity to repair after an acute insult, even one that causes complete organ failure. This regenerative response is characterized by robust proliferation of epithelial cells, principally those located in the proximal tubule. Because defining the origin of these reparative cells has important consequences for stem cell and regenerative approaches to treat kidney injury, this area has been the subject of intense investigation and debate. While progress has been made in narrowing the possible origin of these cells to an intratubular source, there has been no consensus between the possibility of a preexisting intratubular stem or progenitor cell versus the possibility that fully differentiated epithelial cells re-enter the cell cycle after injury and generate new proximal tubule cells through self-duplication. This review will summarize the evidence on both sides of this active controversy and provide support for the notion that no preexisting proximal tubule stem cell population exists, but rather all differentiated proximal tubule epithelia have the capacity to proliferate during repair by a mechanism of dedifferentiation and self-duplication.
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影响因子：
168.9
作者：
Benigni, Ariela;Morigi, Marina;Remuzzi, Giuseppe
通讯作者：
Remuzzi, Giuseppe
DOI：
10.1097/01.asn.0000067652.51441.21
发表时间：
2003-06-01
影响因子：
13.6
作者：
Bonventre, JV
通讯作者：
Bonventre, JV
影响因子：
5.2
作者：
Angelotti, Maria Lucia;Ronconi, Elisa;Romagnani, Paola
通讯作者：
Romagnani, Paola
DOI：
10.1002/ar.b.20079
发表时间：
2005-11-01
期刊：
Anatomical Record Part B:The New Anatomist
影响因子：
--
作者：
Carlson, Bruce M.
通讯作者：
Carlson, Bruce M.
影响因子：
4.8
作者：
Kitamura, S;Yamasaki, Y;Makino, H
通讯作者：
Makino, H