Nucleus accumbens shell, but not core, tracks motivational value of salt.
Nucleus accumbens shell, but not core, tracks motivational value of salt.
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伏隔核外壳（而非核心）追踪盐的激励价值。
DOI：
10.1152/jn.00153.2011
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发表时间：
2011
影响因子：
2.5
通讯作者：
Roitman,MitchellF
中科院分区：
文献类型：
--
作者：
Loriaux,AmyL;Roitman,JamieD;Roitman,MitchellF
为了对情感刺激做出适当的反应，我们必须能够在外部和内部环境的变化中跟踪其价值。丘脑核（NAc）是奖赏回路的关键组成部分，但最近的研究表明，NAc编码厌恶和奖赏。它仍然是未知的差异NAc活动是否反映灵活的变化，刺激值时，它是由于生理状态的变化而改变。我们测量了个体NAc神经元的活动时，大鼠口内输注的高渗盐溶液（0.45 M NaCl）在多个会话中，其中动机状态被操纵。这种通常不受欢迎的味道通过钠的消耗而变得有益，这导致了寻找和消费盐的强烈动机。在三种情况下进行记录：当钠充足时（REP），在急性钠缺乏期间（DEP），以及在补充盐至正常钠平衡后（POST）。我们发现，NAc神经元在壳和核心子区域在三种条件下的反应不同。在壳中，我们观察到NAc活性的总体增加时，盐溶液是非首选的（REP），但盐溶液是首选的（DEP）时下降。在核心中，只有在钠平衡恢复后（POST），整体活动才发生显著变化。这些结果进一步支持了NAc对情感刺激的选择性编码，并表明NAc壳层特别参与了基于动机状态的刺激值的灵活编码。
To appropriately respond to an affective stimulus, we must be able to track its value across changes in both the external and internal environment. The nucleus accumbens (NAc) is a critical component of reward circuitry, but recent work suggests that the NAc encodes aversion as well as reward. It remains unknown whether differential NAc activity reflects flexible changes in stimulus value when it is altered due to a change in physiological state. We measured the activity of individual NAc neurons when rats were given intraoral infusions of a hypertonic salt solution (0.45 M NaCl) across multiple sessions in which motivational state was manipulated. This normally nonpreferred taste was made rewarding via sodium depletion, which resulted in a strong motivation to seek out and consume salt. Recordings were made in three conditions: while sodium replete (REP), during acute sodium depletion (DEP), and following replenishment of salt to normal sodium balance (POST). We found that NAc neurons in the shell and core subregions responded differently across the three conditions. In the shell, we observed overall increases in NAc activity when the salt solution was nonpreferred (REP) but decreases when the salt solution was preferred (DEP). In the core, overall activity was significantly altered only after sodium balance was restored (POST). The results lend further support to the selective encoding of affective stimuli by the NAc and suggest that NAc shell is particularly involved in flexibly encoding stimulus value based on motivational state.
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影响因子：
2.5
作者：
Nicola, SM;Yun, IA;Fields, HL
通讯作者：
Fields, HL
多巴胺和钠食欲：拮抗剂抑制大鼠假饮氯化钠溶液。
影响因子：
1.9
作者：
Roitman,MF;Schafe,GE;Thiele,TE;Bernstein,IL
通讯作者：
Bernstein,IL
多巴胺和钠的食欲
DOI：
--
发表时间：
1997
期刊：
影响因子：
--
作者：
M. Roitman;G. Schafe;T. E. Thiele;I. Bernstein
通讯作者：
I. Bernstein
大鼠先前发生的一次钠消耗会增强盐的食欲。
影响因子：
1.9
作者：
Sakai,RR;Fine,WB;Epstein,AN;Frankmann,SP
通讯作者：
Frankmann,SP
伏核核、前扣带皮层和杏仁核中央核的选择性兴奋性毒性损伤对大鼠自塑性能的影响。
影响因子：
1.9
作者：
R. Cardinal;J. Parkinson;G. Lachenal;K. M. Halkerston;N. Rudarakanchana;Jeremy Hall;Caroline H. Morrison;S. Howes;T. Robbins;B. Everitt
通讯作者：
B. Everitt