Zebrafish yap1 plays a role in differentiation of hair cells in posterior lateral line.
Zebrafish yap1 plays a role in differentiation of hair cells in posterior lateral line.
复制标题
斑马鱼Yap1在后侧线的毛细胞分化中起作用。
DOI：
10.1038/srep04289
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发表时间：
2014-03-06
影响因子：
4.6
通讯作者：
Korzh V
中科院分区：
文献类型：
--
作者：
Loh SL;Teh C;Muller J;Guccione E;Hong W;Korzh V
进化上保守的Hippo信号通路通过调节细胞增殖和凋亡来控制器官大小，这一过程涉及Yap1。斑马鱼Yap1在神经分化过程中起作用，但其功能尚未完全了解。对增生区域中yap 1表达的详细分析显示，它在耳基板中引起受到吗啉介导的Yap 1敲低影响的侧线系统。对Yap1缺陷胚胎转录组的比较微阵列分析表明，许多基因的表达发生了变化，包括Wnt信号通路，特别是已知在侧线机械感受器发育中发挥作用的Wnt 1a。Yap1的敲低导致机械感受器的分化缺陷，并且这种缺陷可以通过Yap1a mRNA来挽救。我们的研究揭示了Yap 1在机械感觉细胞分化过程中对Wnt信号通路及其靶点Prox1a的调节作用。
The evolutionarily conserved Hippo signaling pathway controls organ size by regulating cell proliferation and apoptosis and this process involves Yap1. The zebrafish Yap1 acts during neural differentiation, but its function is not fully understood. The detailed analysis of yap1 expression in proliferative regions, revealed it in the otic placode that gives rise to the lateral line system affected by the morpholino-mediated knockdown of Yap1. The comparative microarray analysis of transcriptome of Yap1-deficient embryos demonstrated changes in expression of many genes, including the Wnt signaling pathway and, in particular, prox1a known for its role in development of mechanoreceptors in the lateral line. The knockdown of Yap1 causes a deficiency of differentiation of mechanoreceptors, and this defect can be rescued by prox1a mRNA. Our studies revealed a role of Yap1 in regulation of Wnt signaling pathway and its target Prox1a during differentiation of mechanosensory cells.
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影响因子：
3.5
作者：
Gaffney CJ;Oka T;Mazack V;Hilman D;Gat U;Muramatsu T;Inazawa J;Golden A;Carey DJ;Farooq A;Tromp G;Sudol M
通讯作者：
Sudol M
影响因子：
4.6
作者：
Fong, SH;Emelyanov, A;Korzh, V
通讯作者：
Korzh, V
DOI：
10.1073/pnas.96.13.7558
发表时间：
1999-06-22
影响因子：
11.1
作者：
Alexandre, D;Ghysen, A
通讯作者：
Ghysen, A
影响因子：
64.5
作者：
Dong, Jixin;Feldmann, Georg;Pan, Duojia
通讯作者：
Pan, Duojia
影响因子：
2.6
作者：
Glasgow, E;Tomarev, SI
通讯作者：
Tomarev, SI