Genomic determinants of epidermal appendage patterning and structure in domestic birds.
Genomic determinants of epidermal appendage patterning and structure in domestic birds.
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DOI：
10.1016/j.ydbio.2017.03.022
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发表时间：
2017-09-15
影响因子：
2.7
通讯作者：
Shapiro MD
中科院分区：
文献类型：
--
作者：
Boer EF;Van Hollebeke HF;Shapiro MD
在许多脊椎动物群体中，表皮附属物的区域身份、图案和结构的变化有助于皮肤的多样性，这在鸟类中可能是最引人注目的。在表皮附属物图案化的开创性工作中，John Saunders和他的同时代人利用家养鸡种内和之间的表皮附属物多样性来确定中胚层-外胚层信号传导在决定皮肤图案化中的重要性。鸡和其他家禽（包括鸽子）的多样性正在推动新一轮研究，以剖析表皮附属物模式的分子遗传基础。正如桑德斯所认识到的那样，家禽不仅是胚胎操作的杰出模型，而且它们也是发现控制正常发育的特定基因和有助于皮肤多样性的突变的理想遗传模型。在这里，我们回顾了最近的遗传和基因组的方法来揭示表皮宏观模式，微观模式和结构变异的基础。我们还提出了新的结果，确认在两个肢体身份基因的表达变化羽足鸽，附件结构和身份的变化的情况下。
Variation in regional identity, patterning, and structure of epidermal appendages contributes to skin diversity among many vertebrate groups, and is perhaps most striking in birds. In pioneering work on epidermal appendage patterning, John Saunders and his contemporaries took advantage of epidermal appendage diversity within and among domestic chicken breeds to establish the importance of mesoderm-ectoderm signaling in determining skin patterning. Diversity in chickens and other domestic birds, including pigeons, is driving a new wave of research to dissect the molecular genetic basis of epidermal appendage patterning. Domestic birds are not only outstanding models for embryonic manipulations, as Saunders recognized, but they are also ideal genetic models for discovering the specific genes that control normal development and the mutations that contribute to skin diversity. Here, we review recent genetic and genomic approaches to uncover the basis of epidermal macropatterning, micropatterning, and structural variation. We also present new results that confirm expression changes in two limb identity genes in feather-footed pigeons, a case of variation in appendage structure and identity.
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影响因子：
9.2
作者：
Domyan, Eric T.;Guernsey, Michael W.;Kronenberg, Zev;Krishnan, Shreyas;Boissy, Raymond E.;Vickrey, Anna I.;Rodgers, Clifford;Cassidy, Pamela;Leachman, Sancy A.;Fondon, John W., III;Yandell, Mark;Shapiro, Michael D.
通讯作者：
Shapiro, Michael D.
影响因子：
--
作者：
BROTMAN, HF
通讯作者：
BROTMAN, HF
影响因子：
4.4
作者：
Bed'hom B;Vaez M;Coville JL;Gourichon D;Chastel O;Follett S;Burke T;Minvielle F
通讯作者：
Minvielle F
影响因子：
--
作者：
AMPRINO, R;CAMOSSO, M
通讯作者：
CAMOSSO, M
影响因子：
2.8
作者：
BROTHWELL, D
通讯作者：
BROTHWELL, D