Motility of Different Gastric Helicobacter spp.

Motility of Different Gastric Helicobacter spp.
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DOI:
10.3390/microorganisms11030634
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发表时间:
2023-03-01
期刊:
影响因子:
4.5
通讯作者:
Fox JG
Fox JG
中科院分区:
生物学3区
文献类型:
--
作者:
Bansil R;Constantino MA;Su-Arcaro C;Liao W;Shen Z;Fox JG

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螺杆菌属,包括著名的人类胃病原体H幽门螺杆菌可导致人类和其他哺乳动物的胃病。它们是革兰氏阴性细菌,定植于胃上皮,并使用其多个鞭毛移动穿过保护性胃粘液层。不同螺杆菌的鞭毛。不同的位置和数量。本文综述了具有不同鞭毛结构和细胞形状的不同物种的游泳特性。所有螺杆菌属使用运行-反向-重定向机制在水溶液中以及在胃粘蛋白中游泳。比较了H. pylori的细胞形状和鞭毛数量的变化表明,它们的游动速度随着鞭毛数量的增加而增加,并且随着螺旋状细胞体形状的增加而有所增强。对H. suis具有双极鞭毛,比单极H. pylori、H.猪在游动时显示出多种鞭毛定向模式。胃粘蛋白的pH依赖性粘度和凝胶化显著影响螺杆菌的运动。在没有尿素的情况下,这些细菌在pH < 4的粘蛋白凝胶中不游泳,即使它们的鞭毛束旋转。
Helicobacter spp., including the well-known human gastric pathogen H. pylori, can cause gastric diseases in humans and other mammals. They are Gram-negative bacteria that colonize the gastric epithelium and use their multiple flagella to move across the protective gastric mucus layer. The flagella of different Helicobacter spp. vary in their location and number. This review focuses on the swimming characteristics of different species with different flagellar architectures and cell shapes. All Helicobacter spp. use a run-reverse-reorient mechanism to swim in aqueous solutions, as well as in gastric mucin. Comparisons of different strains and mutants of H. pylori varying in cell shape and the number of flagella show that their swimming speed increases with an increasing number of flagella and is somewhat enhanced with a helical cell body shape. The swimming mechanism of H. suis, which has bipolar flagella, is more complex than that of unipolar H. pylori. H. suis exhibits multiple modes of flagellar orientation while swimming. The pH-dependent viscosity and gelation of gastric mucin significantly impact the motility of Helicobacter spp. In the absence of urea, these bacteria do not swim in mucin gel at pH < 4, even though their flagellar bundle rotates.
螺旋形和棒状细菌在螺旋轨迹中游泳,几乎没有螺旋形的推进。
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