Temporal Progression and Spatial Repeatability of Tear Breakup
Temporal Progression and Spatial Repeatability of Tear Breakup
复制标题
泪液破裂的时间进展和空间重复性
DOI：
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发表时间：
2006
影响因子：
1.4
通讯作者：
Jenni A Wilkinson
中科院分区：
文献类型：
--
作者：
Haixia Liu;C. Begley;R. Chalmers;G. Wilson;S. P. Srinivas;Jenni A Wilkinson
目的。这项研究使用图像分析来比较干眼和正常受试者泪膜破裂区域(AB)的时间进程和空间复发。方法：研究方法。10名对照组和10名干眼症受试者在凝视泪水破裂动力学测试中诱发泪水破裂，该测试包括尽可能长时间地睁一只眼睛，称为最大眨眼间隔(MBI)。泪膜荧光的视频成像测量了AB的发生和发展。绘制了AB位置和面积图。通过自定义的MatLab程序计算从第一次试验开始的ABS的进展、泪液破裂或干区生长率(DAGR)以及相隔5分钟的三次连续试验中ABS的重叠。结果。与对照组相比，干眼症患者眨眼前的最后AB显著增加(30.7%±12.5%比16.1%±9.2%)，MBI显著减少(平均19.5±9.0秒比56.5±38.9秒)(p<；0.05，Mann-Whitney U检验)。干眼症受试者的DAGR是对照组的四倍，他们的中央角膜表现出明显更多的泪液破裂(P<；0.0001，Mann-Whitney U检验)。当三个连续试验的最终图像重叠时，三个试验中同一位置发生泪水破裂的频率高于独立点重叠时的预期。结论。结构上的影响，如“黑线”或角膜盖缺陷，似乎影响了同一区域内破裂的复发。S泪膜定量图像分析技术表明，干眼症受试者的泪膜在最初的第一次破裂后继续迅速失稳；因此，低色调与高DAGR是相结合的。与对照组相比，干眼症受试者的中央角膜区域似乎特别容易受到泪水破裂增加的影响。
Purpose. This study used image analysis to compare the temporal progression and spatial reoccurrence of the area of tear film breakup (AB) in dry eye and normal subjects. Methods. Tear breakup was induced in 10 control and 10 dry eye subjects during the Staring Tear Breakup Dynamics (S-TBUD) test, which involves keeping one eye open for as long as possible, termed the maximum blink interval (MBI). Video imaging of tear film fluorescence measured the onset and progression of the AB. AB location and area were mapped. The progression of ABs from the first trial, the rate of tear breakup or dry area growth rate (DAGR), and the overlap of ABs in three successive trials 5 minutes apart were computed by custom MATLAB programs. Results. The final AB before the blink was significantly greater (average, 30.7% ± 12.5% vs. 16.1% ± 9.2%) and the MBI was significantly less (average, 19.5 ± 9.0 seconds vs. 56.5 ± 38.9 seconds) among dry eye subjects compared with controls (p < 0.05, Mann-Whitney U test). The DAGR was four times greater among dry eye subjects, who also showed significantly more tear breakup in the central cornea than controls (p < 0.0001, Mann-Whitney U test). When the final image from three successive trials was overlapped, tear breakup occurred more often in the same location in three trials than would be expected by the overlap of independent points. Conclusions. Structural influences such as the “black line” or corneal lid defects appeared to influence the recurrence of breakup in the same region. The S-TBUD quantitative image analysis technique demonstrates that the tear film of subjects with dry eye continues to rapidly destabilize after an initial first break; thus, a low TBUT was combined with a high DAGR. The central corneal region of subjects with dry eye appeared especially susceptible to increased tear breakup when compared with controls.
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影响因子：
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作者：
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通讯作者：
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通讯作者：
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影响因子：
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通讯作者：
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