Overexpression of cancer cell-derived immunoglobulin G correlates with poor prognosis in gastric cancer patients
Overexpression of cancer cell-derived immunoglobulin G correlates with poor prognosis in gastric cancer patients
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癌细胞源性免疫球蛋白 G 的过度表达与胃癌患者的不良预后相关
DOI：
10.21037/8033
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发表时间：
2016-06
影响因子：
0.9
通讯作者：
JIAFU JI
中科院分区：
文献类型：
--
作者：
LIN LI;XIAOJING CHENG;ZHIXUE ZHENG;XIAOFANG XING;XIAOHONG WANG;LIANGHAI ZHANG;TING GUO;HONG DU;YING HU;XIAOYAN QIU;XIANZI WEN;JIAFU JI
背景：多种人类上皮性肿瘤产生胞浆免疫球蛋白(Ig)G。最近的研究表明，Ig与肿瘤的发生有关。本研究旨在确定胃癌组织中癌细胞衍生免疫球蛋白的表达水平与临床参数的关系。
癌症(GC)。
方法：采用免疫组织化学方法检测231例原发胃癌组织中癌细胞来源的免疫球蛋白G的表达。评估癌细胞衍生的免疫球蛋白在细胞增殖、迁移和侵袭中的作用。
结果：胃癌组织中Ig G高表达(42.2%，46/109)，癌旁组织中高表达(11.0%，12/109，P<0.05)。单因素分析，免疫球蛋白阳性组5年总生存率显著低于阴性组(P=0.0361)。多因素分析显示，免疫球蛋白表达是影响胃癌患者5年总生存期的独立预后指标(P=0.018)。此外，通过短干扰RNA(SiRNA)敲除免疫球蛋白G可减少GC细胞的增殖、迁移和侵袭。
结论：癌细胞衍生的免疫球蛋白的过度表达可能与胃癌的进展有关，有望成为预测胃癌患者预后的新的生物标志物。
Background: Various human epithelial origin cancers produce cytoplasmic immunoglobulin (Ig) G. Recent studies have elucidated that it was related with the tumorigenesis. This study was aimed to identify relationship between the cancer cell-derived IgG expression level and clinical parameters in gastric
cancer (GC).
Methods: Cancer cell-derived IgG expression was assessed using immunohistochemistry analysis in 231 primary GC tissues. The role of cancer cell-derived IgG on cell proliferation, migration and invasion were assessed.
Results: Our results indicated that IgG was overexpressed in GC tissues (42.2%, 46/109) than in adjacent tissues (11.0%, 12/109, P vs. 37.2%, respectively). Upon univariate analysis, IgG positive group had significantly lower 5-year overall survival than the negative group (P=0.0361). Multivariate analysis showed IgG expression was an independent prognostic indicator for 5-year overall survival of patients with GC (P=0.018). Furthermore, knockdown of IgG by short interfering RNA (siRNA) resulted in reducing proliferation, migration and invasion of GC cell.
Conclusions: Our results showed that cancer cell-derived IgG overexpression might be correlated with GC progression, and would be a novel biomarker to predict the prognosis of patients with GC.
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人结直肠癌中 IgG 的表达及其与癌细胞行为的关系
影响因子：
3.7
作者：
Niu N;Zhang J;Huang T;Sun Y;Chen Z;Yi W;Korteweg C;Wang J;Gu J
通讯作者：
Gu J
DOI：
10.1016/s1278-3218(02)00178-6
发表时间：
2002-06
期刊：
The New England journal of medicine
影响因子：
--
作者：
J. Macdonald;S. Smalley;J. Benedetti;S.A Hundhal;N. Estes;G.N Stemmermannn;D. Haller;J. Ajani-
通讯作者：
J. Macdonald;S. Smalley;J. Benedetti;S.A Hundhal;N. Estes;G.N Stemmermannn;D. Haller;J. Ajani-
影响因子：
11.2
作者：
Xiaoyan Qiu;Xiao-hui Zhu;Liang Zhang;Y. Mao;Jian Zhang;Peng Hao;Guohui Li;Peng Lv;Zhixin Li
通讯作者：
Xiaoyan Qiu;Xiao-hui Zhu;Liang Zhang;Y. Mao;Jian Zhang;Peng Hao;Guohui Li;Peng Lv;Zhixin Li
影响因子：
3.6
作者：
Lee, Gregory;Laflamme, Emily;Ting, Hong Hoi
通讯作者：
Ting, Hong Hoi
影响因子：
3.6
作者：
Zheng, Hui;Li, Ming;Cao, Ya
通讯作者：
Cao, Ya