Periodontitis: a host-mediated disruption of microbial homeostasis. Unlearning learned concepts.
Periodontitis: a host-mediated disruption of microbial homeostasis. Unlearning learned concepts.
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DOI：
10.1111/j.1600-0757.2012.00450.x
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发表时间：
2013-06
影响因子：
18.6
通讯作者：
Van Dyke TE
中科院分区：
文献类型：
--
作者：
Bartold PM;Van Dyke TE
当现有的概念不能充分解决已知的因素或被新的证据证明无效时，新的概念就会出现。几十年来，牙周炎一直被认为是由特定的细菌或细菌群引起的，因此，治疗方案主要基于抗感染疗法。然而，对当前数据的仔细检查导致人们质疑这些细菌是牙周炎的原因还是结果。良好的证据表明，它确实是宿主对口腔细菌的反应，导致牙龈炎中注意到的组织变化。这些变化导致龈下环境的改变，有利于“牙周病原体”的出现，如果遗传和外部环境条件有利于疾病的发展，则会导致牙周炎的发展。因此，似乎确实是牙龈炎发展过程中发生的最初早期宿主炎症和免疫反应，而不是特定细菌或其所谓的毒力因子决定了牙周炎是否发生和进展。在这篇综述中，我们认为这些概念和它们的潜力，改变我们的看法和管理炎症性牙周病的方式。
New concepts evolve when existing ones fail to address known factors adequately or are invalidated by new evidence. For decades periodontitis has been considered to be caused by specific bacteria or groups of bacteria and, accordingly, treatment protocols have largely been based on anti‐infective therapies. However, close inspection of current data leads one to question whether these bacteria are the cause or the result of periodontitis. Good evidence is emerging to suggest that it is indeed the host response to oral bacteria that leads to the tissue changes noted in gingivitis. These changes lead to an altered subgingival environment that favors the emergence of ‘periodontal pathogens’ and the subsequent development of periodontitis if the genetic and external environmental conditions are favorable for disease development. Thus, it seems that it is indeed the initial early host‐inflammatory and immune responses occurring during the development of gingivitis, and not specific bacteria or their so‐called virulence factors, which determine whether periodontitis develops and progresses. In this review we consider these concepts and their potential to change the way in which we view and manage the inflammatory periodontal diseases.
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DOI：
10.4049/jimmunol.1100150
发表时间：
2011-10-01
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Campbell EL;Serhan CN;Colgan SP
通讯作者：
Colgan SP
影响因子：
4.9
作者：
Bosnar, M;Kelneric, Z;Parnham, MJ
通讯作者：
Parnham, MJ
影响因子：
3.1
作者：
Darveau, Richard P.
通讯作者：
Darveau, Richard P.
DOI：
10.1124/jpet.109.155838
发表时间：
2009-10-01
影响因子：
3.5
作者：
Bosnar, Martina;Bosnjak, Berislav;Haber, Vesna Erakovic
通讯作者：
Haber, Vesna Erakovic
影响因子：
9.4
作者：
Griffen, AL;Becker, MR;Leys, EJ
通讯作者：
Leys, EJ