Protective effects of quercetin on liver injury induced by ethanol.
Protective effects of quercetin on liver injury induced by ethanol.
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DOI：
10.4103/0973-1296.62900
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发表时间：
2010-04
影响因子：
0.7
通讯作者：
Chen X
中科院分区：
文献类型：
--
作者：
Chen X
槲皮素是一种多来源的天然化合物，具有广泛的生物药理作用，如抗氧化、直接清除自由基、保肝作用等。本研究旨在探讨槲皮素对乙醇所致大鼠肝损伤的干预作用。本研究纳入连续10天口服50%乙醇导致细胞坏死、纤维化和炎症浸润的大鼠。与健康大鼠相比，乙醇处理的大鼠血浆中 AST、ALT ADH、γ-GT、TG 和肝组织中 MDA 含量较高，而肝组织中 GSH 含量较低。乙醇处理后大鼠血浆中IL-1β、IL-1、IL-6、IL-8、TNF-α等细胞因子水平也显着升高，IL-10水平明显降低。槲皮素预防同步治疗14 d，AST、ALT ADH、γ-GT、TG、MDA含量，IL-1β、IL-1、IL-6、IL-8、TNF-α水平明显降低，GSH、IL-10水平明显升高。推测槲皮素通过多种机制的相互作用，对乙醇引起的大鼠肝损伤具有一定的保护作用。
Quercetin, a natural compound of multiple origins, has broad biopharmacological effects, such as antioxidant, directly scavenging free radical, and hepatoprotectivity effects. This study is designed to investigate the interveneous effect of quercetin on liver injury induced by ethanol in rats. The rats that were orally treated with 50% ethanol for continuous ten days, which resulted in cell necrosis, fibrosis and inflammatory infiltration, were included in this study. Higher contents of AST, ALT ADH, γ-GT, TG in plasma and MDA in liver tissue, and lower content of GSH in liver tissue were highlighted in ethanol-treated rats when compared with healthy ones. The levels of cytokines such as IL-1β, IL-1, IL-6, IL-8, and TNF-α in rats plasma were also significantly enhanced, and level of IL-10 was obviously lowered through ethanol treatment. By preventive and synchronism treatment with quercetin for fourteen days, the contents of AST, ALT ADH, γ-GT, TG and MDA, and levels of IL-1β, IL-1, IL-6, IL-8, and TNF-α were significantly reduced, whereas GSH and level of IL-10 were obviously increased. It may be deduced that quercetin, by multiple mechanisms interplay, demonstrated somewhat protective effect on liver injury induced by ethanol in rats.
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影响因子：
3.9
作者：
CLEMENS, DL;HALGARD, CM;TUMA, DJ
通讯作者：
TUMA, DJ
影响因子：
6.1
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通讯作者：
Lieber, CS
影响因子：
2
作者：
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通讯作者：
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影响因子：
5
作者：
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通讯作者：
Dobson, VL
影响因子：
4.2
作者：
Bastianetto, S;Quirion, R
通讯作者：
Quirion, R