Fluorine-Retentive Strategies for the Functionalization of gem-Difluoroalkenes.
Fluorine-Retentive Strategies for the Functionalization of gem-Difluoroalkenes.
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DOI：
10.1055/a-1547-9270
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发表时间：
2021-11
期刊：
影响因子：
--
通讯作者：
Altman RA
中科院分区：
文献类型：
--
作者：
Sorrentino JP;Altman RA
gem-Difluoroalkenes are readily available fluorinated building blocks, and the fluorine-induced electronic perturbations of the alkenes enables a wide array of selective functionalization reactions. However, many reactions of gem-difluoroalkenes result in a net C─F functionalization to generate monofluorovinyl products or addition of F to generate trifluoromethyl-containing products. In contrast, fluorine-retentive strategies for the functionalization of gem-difluoroalkenes remain less generally developed, and is now becoming a rapidly developing area. This review will present the development of fluorine-retentive strategies including electrophilic, nucleophilic, radical, and transition metal catalytic strategies with an emphasis on key physical organic and mechanistic aspects that enable reactivities.
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