Seroconversion issues among out-of-treatment injection drug users.
Seroconversion issues among out-of-treatment injection drug users.
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停止治疗的注射吸毒者的血清转化问题。
DOI：
10.1080/02791072.1998.10399705
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发表时间：
1998
期刊：
影响因子：
--
通讯作者：
Trubatch,B
中科院分区：
文献类型：
--
作者：
Fisher,DG;Fenaughty,AM;Trubatch,B
文献中报道了吸毒者中HIV感染的许多危险因素。然而，这些研究大多是以当地样本进行的，通常样本量有限。国家药物滥用问题研究所自1991年以来资助了一项艾滋病社区外展/干预研究合作协议，该协议产生了一个国家数据库。对文献中发现的关联进行了测试，以确定它们是否在这个国家数据库中重复。CA国家数据库拥有完整的数据，包括相隔6个月对6970名基线血清阴性的DRQG使用者的抽血。没有发生血清事件的网站被排除在分析之外。文献中确定的29个风险因素在国家数据库中进行了双变量测试。在3752个危险人年中，有56个血清事件病例(基线HIV血清阴性和随访HIV血清阳性者)，每100个危险人年的血清转换率为1.49(CI 1.05，1.94)。数据被作为一个整体数据集进行分析，并按高流行率和低流行率对站点进行分层。在总体分析中，与血清转换相关的危险因素是注射任何药物的次数、注射过任何药物的时间、注射可卡因的天数、注射可卡因的次数和注射快速球的次数(这些变量具有30天的时间参照性)。同样重要的是以前使用过的注射设备最近的使用情况。高发地点显示注射任何药物的次数、注射可卡因的天数和注射快速球的次数都有关联。低流行率网站显示，注射任何药物和注射可卡因的天数都有关联。这些发现突显了注射吸毒，特别是可卡因注射的重要性，因为它是最近血清转换的主要风险因素。
Many risk factors for HIV incidence among drug users have been reported in the literature. However most of these studies have been with local samples, and typically have had limited sample sizes. The National Institute on Drug Abuse (NIDA) funded a Cooperative Agreement for AIDS Community-Based Outreach/Intervention Research (CA) since 1991 that produced a national database. Associations found in the literature were tested to determine whether they were replicated on this national database. The CA national database had complete data, including blood draws six months apart, on 6,970 drqg users who were seronegative at baseline. Sites that had no seroincident cases were excluded from the analysis. Twenty-nine risk factors identified in the literature were tested on the national database on a bivariate basis. There were 56 seroincident cases (those who were HIV-seronegative at baseline and HIV-seropositive at follow-up) out of 3752 person years at risk, for a seroconversion rate of 1.49 (CI 1.05, 1.94) per 100 person years at risk. Data were analyzed both as a whole dataset and with the sites stratified by high and low prevalence. In the overall analysis, risk factors associated with seroconversion were times injected any drug, ever injected any drug, days injected cocaine, times injected cocaine, and times injected speedball (these variables had a 30-day time referent). Also significant was how recently formerly-used injection equipment was used. Highprevalence sites revealed associations for times injected any drug, days injected cocaine, and times injected speedball. Low-prevalence sites revealed associations for injected any drug and days injected cocaine. These findings highlight the importance of injection drug use, especially cocaine injection, as a major risk factor in recent seroconversion.
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洛杉矶注射吸毒者中与药物相关的艾滋病毒风险行为和可卡因偏好
影响因子：
0.8
作者：
D. Longshore;M. Anglin;S. Hsieh;K. Annon
通讯作者：
K. Annon
静脉吸毒者中的反社会人格障碍和艾滋病毒感染。
DOI：
10.1176/ajp.150.1.53
发表时间：
1993
期刊：
The American journal of psychiatry
影响因子：
--
作者：
Brooner,RK;Greenfield,L;Schmidt,CW;Bigelow,GE
通讯作者：
Bigelow,GE
毒品、性和艾滋病风险
DOI：
--
发表时间：
1990
期刊：
影响因子：
--
作者：
D. Chitwood;M. Comerford
通讯作者：
M. Comerford
低发地区艾滋病预防工作。
影响因子：
2.8
作者：
M. Hochhauser
通讯作者：
M. Hochhauser
影响因子：
3.8
作者：
CHIASSON, MA;STONEBURNER, RL;JAFFE, HW
通讯作者：
JAFFE, HW