Elevated striatal γ-aminobutyric acid in youth with major depressive disorder.
Elevated striatal γ-aminobutyric acid in youth with major depressive disorder.
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DOI：
10.1016/j.pnpbp.2018.06.004
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发表时间：
2018-08-30
影响因子：
5.6
通讯作者：
Gabbay V
中科院分区：
文献类型：
--
作者：
Bradley KA;Alonso CM;Mehra LM;Xu J;Gabbay V
γ-氨基丁酸（GABA）的改变已被假设在精神疾病的发病机制中发挥作用。我们以前的工作已经明确地将前扣带皮层（ACC）GABA缺陷与青少年重度抑郁症（MDD）的快感缺乏联系起来。由于快感缺失反映了奖赏回路的变化，我们试图扩大这项调查，并在同一青少年人群中检查另一个关键的奖赏相关区域纹状体的GABA水平。36名青年[20名MDD患者和16名健康对照;（HC）]，年龄12至21岁，接受了J编辑质子磁共振波谱（1H MRS），其中测量了纹状体和ACC体素中的GABA水平。GABA水平进行了比较组间和体素之间的位置，并进行了检查，与临床病理学，如抑郁症的严重程度，快感缺乏，焦虑和自杀。抑郁的年轻人在纹状体中的GABA水平出乎意料地高于HC。在抑郁和健康的青年，GABA水平在纹状体高于ACC，而抑郁青年的差异更大。此外，在抑郁的青年，较高的纹状体GABA以上的平均HC与较低的ACC GABA以下的平均HC。在这个小样本中，纹状体GABA与临床神经病学无关。总之，这些研究结果表明，较高的纹状体GABA水平可能作为一个结果，较低的ACC GABA在抑郁症青少年的一些补偿功能。也有可能，像较低的ACC GABA一样，较高的纹状体GABA可能只是青少年抑郁症的另一个病理特征。
Alterations in γ-aminobutyric acid (GABA) have been hypothesized to play a role in the pathogenesis of psychiatric illness. Our previous work has specifically linked anterior cingulate cortex (ACC) GABA deficits with anhedonia in youth with major depressive disorder (MDD). As anhedonia reflects alterations within the reward circuitry, we sought to extend this investigation and examine GABA levels in another key reward-related region, the striatum, in the same adolescent population. Thirty-six youth [20 with MDD and 16 healthy controls; (HC)], ages 12 to 21 years old, underwent J-edited proton magnetic resonance spectroscopy (1H MRS) whereby GABA levels were measured in striatal and ACC voxels. GABA levels were compared between groups and between voxel positions and were examined in relation to clinical symptomatology, such as depression severity, anhedonia, anxiety, and suicidality. Depressed youth had unexpectedly higher GABA levels in the striatum compared to HC. In both depressed and healthy youth, GABA levels were higher in the striatum than in the ACC, while the differences in depressed youth were greater. Moreover, in depressed youth, higher striatal GABA above the mean of HCs was correlated with lower ACC GABA below the mean of HCs. Striatal GABA was not correlated with clinical symptomatology in this small sample. Together, these findings suggest that higher striatal GABA levels may serve some compensatory function as a result of lower ACC GABA in depressed adolescents. It is also possible that, like lower ACC GABA, higher striatal GABA might simply be another pathological feature of adolescent depression.
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影响因子：
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作者：
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DOI：
10.1016/j.euroneuro.2015.04.025
发表时间：
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期刊：
European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology
影响因子：
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作者：
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